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1
Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources.原卟啉锡在体内抑制血红素酶促分解代谢的证据。抑制来自放射性标记的内源性和外源性血红素来源的14CO生成。
J Exp Med. 1987 Apr 1;165(4):1195-200. doi: 10.1084/jem.165.4.1195.
2
Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production.锡原卟啉抑制高胆红素血症机制的研究。血红素氧化及胆红素生成的抑制作用。
J Clin Invest. 1985 Feb;75(2):513-21. doi: 10.1172/JCI111727.
3
Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism.将锡原卟啉的C2和C4乙烯基还原以形成锡中卟啉，可显著增强金属卟啉在体内抑制血红素分解代谢的能力。
Arch Biochem Biophys. 1987 May 15;255(1):64-74. doi: 10.1016/0003-9861(87)90294-3.
4
The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.当锡原卟啉竞争性抑制血红素加氧酶时，肝脏会将大量血红素排泄到胆汁中。
Proc Natl Acad Sci U S A. 1985 Feb;82(3):896-900. doi: 10.1073/pnas.82.3.896.
5
Sn-protoporphyrin rapidly and markedly enhances the heme saturation of hepatic tryptophan pyrrolase. Evidence that this synthetic metalloporphyrin increases the functional content of heme in the liver.锡原卟啉能迅速且显著地提高肝脏色氨酸吡咯酶的血红素饱和度。有证据表明这种合成金属卟啉可增加肝脏中血红素的功能含量。
J Clin Invest. 1985 Jan;75(1):302-5. doi: 10.1172/JCI111689.
6
Sn-protoporphyrin lowers serum bilirubin levels, decreases biliary bilirubin output, enhances biliary heme excretion and potently inhibits hepatic heme oxygenase activity in normal human subjects.锡原卟啉可降低正常人血清胆红素水平，减少胆汁胆红素排出量，增加胆汁血红素排泄，并有效抑制肝脏血红素加氧酶活性。
Hepatology. 1988 May-Jun;8(3):625-31. doi: 10.1002/hep.1840080331.
7
Recovery of exogenous heme as carbon monoxide and biliary heme in adult rats after tin protoporphyrin treatment.原卟啉锡治疗成年大鼠后外源性血红素作为一氧化碳和胆汁血红素的恢复情况。
J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):302-6. doi: 10.1097/00005176-198703000-00025.
8
Tin protoporphyrin inhibits carbon monoxide production in adult mice.锡原卟啉抑制成年小鼠一氧化碳的产生。
Pediatr Res. 1985 Jan;19(1):94-6. doi: 10.1203/00006450-198501000-00025.
9
Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.内源性肝血红素通过不产生一氧化碳的途径进行降解。对正常大鼠肝脏和原代肝细胞培养的研究。
J Clin Invest. 1980 May;65(5):1135-40. doi: 10.1172/JCI109767.
10
Inhibition of carbon monoxide production by tin-protoporphyrin.锡原卟啉对一氧化碳生成的抑制作用。
J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):167-71.

引用本文的文献

1
Stimulation of the human mitochondrial transporter ABCB10 by zinc-mesoporphrin.锌-中卟啉对人线粒体转运蛋白 ABCB10 的刺激作用。
PLoS One. 2020 Nov 30;15(11):e0238754. doi: 10.1371/journal.pone.0238754. eCollection 2020.
2
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans.血红素加氧酶-1可预防啮齿动物和人类因香烟烟雾引起的气道黏液高分泌。
Am J Pathol. 2008 Oct;173(4):981-92. doi: 10.2353/ajpath.2008.070863. Epub 2008 Sep 11.
3
Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/reperfusion injury.临床使用的麻醉剂异氟烷诱导血红素加氧酶-1可保护大鼠肝脏免受缺血/再灌注损伤。
Ann Surg. 2007 Jun;245(6):931-42. doi: 10.1097/01.sla.0000256891.45790.4d.
4
Sn-protoporphyrin blocks the increase in serum bilirubin levels that develops postnatally in homozygous Gunn rats.锡原卟啉可阻止纯合子冈恩大鼠出生后血清胆红素水平的升高。
J Exp Med. 1988 Mar 1;167(3):1247-52. doi: 10.1084/jem.167.3.1247.

本文引用的文献

1
The formation of carbon monoxide during peroxidation of microsomal lipids.微粒体脂质过氧化过程中一氧化碳的形成。
Biochem Biophys Res Commun. 1976 Dec 20;73(4):850-7. doi: 10.1016/0006-291x(76)90199-6.
2
Microbial production of carbon monoxide from flavonoids.微生物从黄酮类化合物中生产一氧化碳。
Nature. 1961 Feb 11;189:510-1. doi: 10.1038/189510a0.
3
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation.锡原卟啉IX预防新生儿高胆红素血症，锡原卟啉IX是血红素氧化的一种有效竞争性抑制剂。
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6466-70. doi: 10.1073/pnas.78.10.6466.
4
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model.新生儿黄疸的化学预防：锡原卟啉在动物模型中的效能
Science. 1982 Sep 24;217(4566):1250-2. doi: 10.1126/science.6896768.
5
Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation.牛脾血红素加氧酶的纯化及性质。血红素氧化抑制剂的氨基酸组成及作用位点。
J Biol Chem. 1982 Jul 10;257(13):7778-85.
6
Control of heme oxygenase and plasma levels of bilirubin by a synthetic heme analogue, tin-protoporphyrin.合成血红素类似物锡原卟啉对血红素加氧酶和血浆胆红素水平的调控
Hepatology. 1984 Mar-Apr;4(2):336-41. doi: 10.1002/hep.1840040227.
7
Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase.锡原卟啉的组织分布与处置，血红素加氧酶的一种强效竞争性抑制剂
J Pharmacol Exp Ther. 1984 Feb;228(2):327-33.
8
Early labeling of bilirubin from glycine and delta-aminolevulinic acid in bile fistula dogs, with special reference to stimulated versus suppressed erythropoiesis.胆管造瘘犬中胆红素从甘氨酸和δ-氨基乙酰丙酸的早期标记，特别涉及红细胞生成的刺激与抑制
Metabolism. 1966 Dec;15(12):1129-39. doi: 10.1016/0026-0495(66)90103-x.
9
The sources of bile pigment in the rat: studies of the "early labeled" fraction.大鼠胆汁色素的来源：“早期标记”部分的研究
J Clin Invest. 1966 Oct;45(10):1569-86. doi: 10.1172/JCI105463.
10
Bilirubin formation in the liver from nonhemoglobin sources. Experiments with isolated, perfused rat liver.肝脏中来自非血红蛋白来源的胆红素生成。对离体灌注大鼠肝脏的实验。
Blood. 1965 Dec;26(6):823-9.

原卟啉锡在体内抑制血红素酶促分解代谢的证据。抑制来自放射性标记的内源性和外源性血红素来源的14CO生成。

Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources.

作者信息

Landaw S A, Sassa S, Drummond G S, Kappas A

出版信息

J Exp Med. 1987 Apr 1;165(4):1195-200. doi: 10.1084/jem.165.4.1195.

DOI:10.1084/jem.165.4.1195
PMID:3559477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188590/
Abstract

Sn-protoporphyrin (SnPP) suppresses generation of 14CO from hepatic heme labeled with delta-aminolevulinic acid (5-[14C]ALA) or from infused [14C]hemin in rats. SnPP administered 1 h before administration of 5-[14C]ALA virtually abolished the peak output of 14CO occurring 2-3 h after injection of this heme precursor, and during the succeeding 12 h reduced 14CO excretion by approximately 61% compared with controls. When [14C]hemin was infused, SnPP diminished 14CO excretion by approximately 50%. These findings, derived from experiments using radiolabeled endogenous and exogenous heme sources, establish conclusively that the synthetic metalloporphyrin SnPP inhibits the oxidative degradation of heme in the intact animal.

摘要

锡原卟啉（SnPP）可抑制大鼠肝脏中由δ-氨基乙酰丙酸（5-[14C]ALA）标记的血红素或注入的[14C]血红素生成14CO。在给予5-[14C]ALA前1小时给予SnPP，实际上消除了注射这种血红素前体后2 - 3小时出现的14CO峰值输出，并且在随后的12小时内，与对照组相比，14CO排泄减少了约61%。当注入[14C]血红素时，SnPP使14CO排泄减少了约50%。这些来自使用放射性标记的内源性和外源性血红素来源的实验结果确凿地表明，合成金属卟啉SnPP在完整动物中抑制血红素的氧化降解。