Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Prog Mol Biol Transl Sci. 2022;189(1):35-65. doi: 10.1016/bs.pmbts.2021.12.002. Epub 2022 Jan 7.
We utilize animal models in urologic research to improve understanding of urinary physiology, determine the etiology of many urologic diseases, and discover and test novel therapeutic interventions. Dogs have a similar urinary tract anatomy and physiology to human and they develop many urologic diseases spontaneously. This chapter offers detailed comparisons of urinary tract anatomy, physiology, and the most common urologic diseases between humans and dogs. Dogs offer a unique opportunity for urologic research because they can be studied in research colonies and in client owned cohorts. Dogs also are among a limited number of non-human species that require continence and socially appropriate urinary behaviors (ex. going to the bathroom outside, training to not have submissive urination, etc.). These features make dogs unique in the animal kingdom and make them an ideal animal model for urologic research.
我们在泌尿科研究中使用动物模型来增进对尿生理的理解，确定许多泌尿科疾病的病因，并发现和测试新的治疗干预措施。狗的尿路解剖结构和生理机能与人相似，并且它们会自发地患上许多泌尿科疾病。本章详细比较了人类和狗的尿路解剖结构、生理机能以及最常见的泌尿科疾病。狗为泌尿科研究提供了一个独特的机会，因为它们可以在研究群体和客户拥有的群体中进行研究。狗也是少数几种需要控制和适当社交行为的非人类物种之一（例如，在外面上厕所，训练不进行顺从性排尿等）。这些特征使狗在动物王国中独一无二，使它们成为泌尿科研究的理想动物模型。
