Biegon A, Israeli M
J Neurochem. 1987 May;48(5):1386-91. doi: 10.1111/j.1471-4159.1987.tb05675.x.
Chronic electroconvulsive shock (ECS) is known to increase the level of serotonin-2 (S2) receptors in male rat brain. Using quantitative autoradiography, we have studied the distribution pattern of these receptors in female as well as male rats and the effect of repeated ECS on the receptor level in both sexes. We find that although the distribution of S2 receptors is generally similar in males and females, they respond differently to repeated ECS. In males we found the expected increase in S2 binding, which was localized to specific cortical, hippocampal, and septal regions. In females, no increase was found in the cortex or septum and relatively small increases were found in the hippocampus. It appears that the regulation of S2 receptors by ECS is sex-dependent.
已知慢性电惊厥休克（ECS）会提高雄性大鼠大脑中血清素-2（S2）受体的水平。我们使用定量放射自显影技术，研究了这些受体在雌性和雄性大鼠中的分布模式，以及重复ECS对两性受体水平的影响。我们发现，虽然S2受体在雄性和雌性中的分布总体相似，但它们对重复ECS的反应不同。在雄性大鼠中，我们发现S2结合预期增加，且这种增加定位于特定的皮质、海马和隔区。在雌性大鼠中，皮质或隔区未发现增加，海马中发现的增加相对较小。看来ECS对S2受体的调节具有性别依赖性。
