Nowak G, Dulinski J
Institute of Pharmacology, Polish Academy of Sciences, Smetna, Poland.
Pharmacol Biochem Behav. 1991 Mar;38(3):691-4. doi: 10.1016/0091-3057(91)90037-3.
The effect of repeated treatment with electroconvulsive shock (ECS) on 5-HT1A and 5-HT2 serotonin receptor density and on serotonin receptor turnover was measured in the rat cerebral cortex. Repeated treatment with ECS produced an increase in the density of 5-HT1A and tended to increase the specific binding of 5-HT2 serotonin receptors. However, the turnover of those receptors remained unchanged. These results are in agreement with previous studies which indicate that repeated ECS treatment up-regulates 5-HT2 receptors and support the contention that 5-HT1A receptors are up-regulated after repeated treatment with ECS; moreover, these data demonstrate that the dynamic characteristics (turnover rates) of serotonin receptors (5-HT1A, 5-HT2) are unaffected after repeated ECS administration.
在大鼠大脑皮层中测量了重复电休克治疗（ECS）对5-HT1A和5-HT2血清素受体密度以及血清素受体周转率的影响。重复ECS治疗使5-HT1A的密度增加，并倾向于增加5-HT2血清素受体的特异性结合。然而，这些受体的周转率保持不变。这些结果与先前的研究一致，先前的研究表明重复ECS治疗会上调5-HT2受体，并支持重复ECS治疗后5-HT1A受体上调的观点；此外，这些数据表明重复给予ECS后血清素受体（5-HT1A、5-HT2）的动态特性（周转率）不受影响。
