Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China; College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang 110122, Liaoning, China; Innovation Institute, China Medical University, China Medical University, Shenyang 110122, Liaoning, China.
Health Sciences Institute, Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang 110122, Liaoning, China; College of Basic Medical Science, Key Laboratory of Medical Cell Biology, Ministry of Education, Key Laboratory of Liaoning Province, China Medical University, Shenyang 110122, Liaoning, China.
Cytokine Growth Factor Rev. 2022 Jun;65:27-38. doi: 10.1016/j.cytogfr.2022.04.008. Epub 2022 May 5.
In recent decades, a dramatic rise has been observed in the prevalence of obesity in childhood and adolescence, along with an increase in fetal microsomia rates. The increased risk of obesity during this key period in development negatively affects the health of the individual later in life. Immune cells residing and recruited to white adipose tissue have been highlighted as important factors contributing to the pathogenesis of childhood obesity. Immune dysfunction in the context of obesity begins early in childhood, which is different from the pathological characteristics and influencing factors of adipose immunity in adults. Here, we explore the current understanding of the roles of childhood and early life events that result in high risks for obesity by influencing adipose tissue immune dysfunction under the pathological condition of obesity. Such knowledge will help in determining the mechanisms of childhood and early life obesity in efforts to ameliorate chronic inflammation-related metabolic diseases.
近几十年来，儿童和青少年肥胖的患病率显著上升，同时胎儿出生体重不足的比例也有所增加。在这个关键的发育阶段，肥胖风险的增加对个体以后的健康产生负面影响。驻留在白色脂肪组织中并被招募到白色脂肪组织中的免疫细胞已被强调为导致儿童肥胖发病机制的重要因素。肥胖症背景下的免疫功能障碍早在儿童期就开始了，这与成人脂肪免疫的病理特征和影响因素不同。在这里，我们探讨了在肥胖病理条件下，通过影响脂肪组织免疫功能障碍，导致肥胖风险高的儿童和生命早期事件的作用的现有认识。这些知识将有助于确定儿童和生命早期肥胖的机制，从而改善与慢性炎症相关的代谢性疾病。
