用于高选择性富集糖肽的无模板介孔聚合物合成
Template-Free Synthesis of Mesoporous Polymers for Highly Selective Enrichment of Glycopeptides.
作者信息
Jin Tian, Xiong Zhichao, Zhu Xiang, Mehio Nada, Chen Yajing, Hu Jun, Zhang Weibing, Zou Hanfa, Liu Honglai, Dai Sheng
机构信息
State Key Laboratory of Chemical Engineering and Department of Chemistry, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian, P. R. China.
出版信息
ACS Macro Lett. 2015 May 19;4(5):570-574. doi: 10.1021/acsmacrolett.5b00235. Epub 2015 May 1.
A facile template-free strategy for the synthesis of mesoporous phenolic polymers with attractive porosities, nitrogen-containing functionalities, and intrinsic hydrophilic skeletons is presented. The resultant polymer has a high BET surface area (548 m g) and mesopore size (13 nm) and exhibits superior glycopeptide-capturing performance, thus, revealing the potential application of mesoporous polymers in highly selective glycopeptide enrichment. This general capture protocol may open up new opportunities for the development of glycoproteomes.
本文提出了一种简便的无模板策略，用于合成具有吸引人的孔隙率、含氮官能团和固有亲水骨架的介孔酚醛聚合物。所得聚合物具有高BET表面积（548 m²/g）和介孔尺寸（13 nm），并表现出优异的糖肽捕获性能，因此揭示了介孔聚合物在高选择性糖肽富集方面的潜在应用。这种通用的捕获方案可能为糖蛋白质组学的发展开辟新的机会。
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