Ono Robert J, Lee Ashlynn L Z, Chin Willy, Goh Wei Sheng, Lee Amelia Y L, Yang Yi Yan, Hedrick James L
IBM Almaden Research Center, 650 Harry Road, San Jose, California 95120, United States.
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, Singapore 138669, Singapore.
ACS Macro Lett. 2015 Sep 15;4(9):886-891. doi: 10.1021/acsmacrolett.5b00527. Epub 2015 Aug 10.
Biodegradable polycarbonate-based ABA triblock copolyelectrolytes were synthesized and formulated into physically cross-linked hydrogels. These biocompatible, cationically, and anionically charged hydrogel materials exhibited pronounced shear-thinning behavior, making them useful for a variety of biomedical applications. For example, we investigated the antimicrobial activity of positively charged thiouronium functionalized hydrogels by microbial growth inhibition assays against several clinically relevant Gram-negative and Gram-positive bacteria. It is noteworthy that these hydrogels exhibited broad spectrum killing efficiencies approaching 100%, thereby rendering these thixotropic materials attractive for treatment of skin and other surface bound infections. Finally, cationic trimethylammonium containing hydrogels and anionic carboxylic acid functionalized hydrogels were utilized to sustain the release of negatively charged (diclofenac) and positively charged (vancomycin) therapeutics, respectively. Collectively, the present work introduces a simple method for formulating charged hydrogel materials that are capable of interacting with various analytes of interest through noncovalent interactions.
合成了基于可生物降解聚碳酸酯的ABA三嵌段共聚电解质，并将其制成物理交联水凝胶。这些具有生物相容性、带阳离子和阴离子电荷的水凝胶材料表现出显著的剪切变稀行为，使其可用于多种生物医学应用。例如，我们通过对几种临床相关革兰氏阴性菌和革兰氏阳性菌的微生物生长抑制试验，研究了带正电荷的硫脲功能化水凝胶的抗菌活性。值得注意的是，这些水凝胶表现出接近100%的广谱杀灭效率，从而使这些触变材料对治疗皮肤和其他表面感染具有吸引力。最后分别利用含阳离子三甲铵的水凝胶和含阴离子羧酸功能化的水凝胶来维持带负电荷（双氯芬酸）和带正电荷（万古霉素）治疗剂的释放。总的来说，本工作介绍了一种制备带电水凝胶材料的简单方法，该材料能够通过非共价相互作用与各种感兴趣的分析物相互作用。
