Department of Stomatology, The Third Xiangya Hospital, Central South University, 410013, Changsha, Hunan, PR China.
State Key Laboratory of Powder Metallurgy, Central South University, 410083, Changsha, Hunan, PR China.
J Mater Sci Mater Med. 2022 May 21;33(6):47. doi: 10.1007/s10856-022-06664-5.
Ti-Zr alloys have gained increasing attention as a new metallic biomaterial, being used as implants for both orthopedics and dentistry. More recently, our group found promising results for the Ti-45Zr alloy, which presented a low elastic modulus, a pronounced and excellent mechanic character, and excellent cell compatibility in vitro. However, its biocompatibility and potential to promote osteogenesis in vivo remained unclear. In the present study, the biocompatibility, osteointegration ability, and immune response effects of the Ti-45Zr alloy were evaluated in animal experiments. The results showed that the alloy had good blood compatibility and no body side effects. After implantation in vivo, the inflammation turned out well and was beneficial to the polarization of macrophages. Additionally, the Ti-45Zr alloy presented a good osteointegration ability. Overall, these results confirmed that the Ti-45Zr alloy can be used as a dental implant material.
钛锆合金作为一种新型金属生物材料受到越来越多的关注，被用作骨科和牙科植入物。最近，我们小组发现 Ti-45Zr 合金有很有前景的结果，该合金具有较低的弹性模量、显著和优异的力学性能以及体外优异的细胞相容性。然而，其体内生物相容性和促进成骨的潜力仍不清楚。在本研究中，通过动物实验评估了 Ti-45Zr 合金的生物相容性、骨整合能力和免疫反应效应。结果表明，该合金具有良好的血液相容性，无身体副作用。体内植入后，炎症反应良好，有利于巨噬细胞的极化。此外，Ti-45Zr 合金具有良好的骨整合能力。总的来说，这些结果证实 Ti-45Zr 合金可用作牙科植入材料。
