1 State Key Laboratory of Powder Metallurgy, Central South University, Changsha, China.
2 Department of Anesthesiology, the Second Xiang Ya Hospital, Central South University, Changsha, China.
J Biomater Appl. 2019 Jan;33(6):766-775. doi: 10.1177/0885328218811052. Epub 2018 Nov 5.
The microstructure, mechanical properties, and in vitro biocompatibility of vacuum-sintered Ti-xZr binary alloys (x = 5, 15, 25, 35, 45 wt%) were investigated. The results indicated that α and α' phase existed in Ti-xZr alloys. The hardness of the Ti-Zr alloys increased as the contents increased and ranged from 473 HV (Ti-5Zr) to 525 HV (Ti-45Zr). Increasing Zr content could lead to an increase in compressive and bending strength. Additionally, the Ti-45Zr alloy exhibited the maximum bending strength of 867.1 MPa and the maximum compressive strength of 1599.8 MPa which were much larger than that of CP-Ti. Moreover, all Ti-Zr alloys showed a lower elastic modulus (ranging from 53.5 to 59.3 GPa) compared with CP-Ti (103 GPa). The in vitro cytotoxicity tests were carried out for biocompatibility evaluation. The alloys presented no cytotoxic effects and the surface of the alloys exhibited great growth conditions for MG-63 cells. The Ti-45Zr alloy exhibited better mechanical properties and biocompatibility. In conclusion, Ti-45Zr alloy is of great potential for dental applications.
研究了真空烧结 Ti-xZr 二元合金（x = 5、15、25、35、45wt%）的微观结构、力学性能和体外生物相容性。结果表明，Ti-Zr 合金中存在 α 和 α'相。Ti-Zr 合金的硬度随含量的增加而增加，范围为 473 HV（Ti-5Zr）至 525 HV（Ti-45Zr）。增加 Zr 含量会导致压缩和弯曲强度增加。此外，Ti-45Zr 合金表现出最大的弯曲强度 867.1 MPa 和最大的压缩强度 1599.8 MPa，远高于 CP-Ti。此外，所有 Ti-Zr 合金的弹性模量（53.5-59.3 GPa）均低于 CP-Ti（103 GPa）。进行了体外细胞毒性试验以评估生物相容性。合金无细胞毒性作用，合金表面对 MG-63 细胞显示出良好的生长条件。Ti-45Zr 合金表现出更好的力学性能和生物相容性。综上所述，Ti-45Zr 合金在牙科应用中具有很大的潜力。
