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Ti-xZr 合金作为牙科种植体材料的细胞相容性。

Cytocompatibility of Ti-xZr alloys as dental implant materials.

机构信息

State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, PR China.

Department of Stomatology, Third Xiangya Hospital, Central South University, Changsha, 410013, PR China.

出版信息

J Mater Sci Mater Med. 2021 Apr 23;32(5):50. doi: 10.1007/s10856-021-06522-w.

DOI:10.1007/s10856-021-06522-w
PMID:33891193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8064977/
Abstract

Ti-xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti-xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti-xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti-45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.

摘要

作为一种新型植入材料，制备了具有低弹性模量和高强度的 Ti-xZr（x=5、15、25、35、45wt%）合金。通过 CCK-8 和死活细胞检测、电子显微镜和实时 PCR 等方法，用成骨样细胞系（MG63）评估了 Ti-xZr 合金的生物相容性。与商业纯钛（cpTi）相比，Ti-xZr 合金无毒，具有更好的生物力学性能。Ti-45Zr 具有最佳的强度/弹性模量比和成骨活性，因此有望用作牙科植入物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/2ea497a47dbb/10856_2021_6522_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/9c5c9d77bdc2/10856_2021_6522_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/891b70a0e668/10856_2021_6522_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/6c2fa94f36c9/10856_2021_6522_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/648a684a1f00/10856_2021_6522_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/2ea497a47dbb/10856_2021_6522_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/9c5c9d77bdc2/10856_2021_6522_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/891b70a0e668/10856_2021_6522_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/6c2fa94f36c9/10856_2021_6522_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/648a684a1f00/10856_2021_6522_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/949b/8064977/2ea497a47dbb/10856_2021_6522_Fig5_HTML.jpg

相似文献

[1]
Cytocompatibility of Ti-xZr alloys as dental implant materials.

J Mater Sci Mater Med. 2021-4-23

[2]
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[3]
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[6]
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[7]
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[8]
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[10]
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引用本文的文献

[1]
Soft tissue integration around dental implants: A pressing priority.

Biomaterials. 2025-6-9

[2]
Zirconia Hybrid Dental Implants Influence the Biological Properties of Neural Crest-Derived Mesenchymal Stromal Cells.

Nanomaterials (Basel). 2024-2-20

[3]
Shaping the Structure and Properties of TiO-ZnO Oxide Coatings Produced by Plasma Electrolytic Oxidation on Titanium Substrate.

Materials (Basel). 2023-11-28

[4]
Mechanical and Biological Properties of Titanium and Its Alloys for Oral Implant with Preparation Techniques: A Review.

Materials (Basel). 2023-10-25

[5]
Green Synthesis of MOF-Mediated pH-Sensitive Nanomaterial AgNPs@ZIF-8 and Its Application in Improving the Antibacterial Performance of AgNPs.

Int J Nanomedicine. 2023

[6]
A review in titanium-zirconium binary alloy for use in dental implants: Is there an ideal Ti-Zr composing ratio?

Jpn Dent Sci Rev. 2023-12

[7]
Transcriptomics-based investigation of molecular mechanisms underlying synergistic antimicrobial effects of AgNPs and Domiphen on the human fungal pathogen .

Front Microbiol. 2023-2-1

[8]
Bone response in vivo of Ti-45Zr alloy as dental implant material.

J Mater Sci Mater Med. 2022-5-21

[9]
Medicated Hydroxyapatite/Collagen Hybrid Scaffolds for Bone Regeneration and Local Antimicrobial Therapy to Prevent Bone Infections.

Pharmaceutics. 2021-7-16

本文引用的文献

[1]
Microstructure, mechanical properties, and preliminary biocompatibility evaluation of binary Ti-Zr alloys for dental application.

J Biomater Appl. 2018-11-5

[2]
Comparison of the osteogenic capability of rat bone mesenchymal stem cells on collagen, collagen/hydroxyapatite, hydroxyapatite and biphasic calcium phosphate.

Regen Biomater. 2018-3

[3]
Is Metal Particle Release Associated with Peri-implant Bone Destruction? An Emerging Concept.

J Dent Res. 2017-11-12

[4]
Binary titanium alloys as dental implant materials-a review.

Regen Biomater. 2017-10

[5]
Can degradation products released from dental implants affect peri-implant tissues?

J Periodontal Res. 2017-8-2

[6]
A comparative study of the bone contact to zirconium and titanium implants after 8 weeks of implantation in rabbit femoral condyles.

Odontology. 2018-1

[7]
Aluminium in brain tissue in familial Alzheimer's disease.

J Trace Elem Med Biol. 2017-3

[8]
Is there scientific evidence favoring the substitution of commercially pure titanium with titanium alloys for the manufacture of dental implants?

Mater Sci Eng C Mater Biol Appl. 2016-10-18

[9]
Evaluation of corrosion resistance of implant-use Ti-Zr binary alloys with a range of compositions.

J Biomed Mater Res B Appl Biomater. 2016-11-18

[10]
Cellular responses of osteoblast-like cells to 17 elemental metals.

J Biomed Mater Res A. 2017-1

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