State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, PR China.
Department of Stomatology, Third Xiangya Hospital, Central South University, Changsha, 410013, PR China.
J Mater Sci Mater Med. 2021 Apr 23;32(5):50. doi: 10.1007/s10856-021-06522-w.
Ti-xZr (x = 5, 15, 25, 35, 45% wt%) alloys with low elastic modulus and high mechanical strength were fabricated as a novel implant material. The biocompatibility of the Ti-xZr alloys was evaluated by osteoblast-like cell line (MG63) in terms of cytotoxicity, proliferation, adhesion, and osteogenic induction using CCK-8 and live/dead cell assays, electron microscopy, and real-time PCR. The Ti-xZr alloys were non-toxic and showed superior biomechanics compared to commercially pure titanium (cpTi). Ti-45Zr had the optimum strength/elastic modulus ratio and osteogenic activity, thus is a promising to used as dental implants.
作为一种新型植入材料，制备了具有低弹性模量和高强度的 Ti-xZr（x=5、15、25、35、45wt%）合金。通过 CCK-8 和死活细胞检测、电子显微镜和实时 PCR 等方法，用成骨样细胞系（MG63）评估了 Ti-xZr 合金的生物相容性。与商业纯钛（cpTi）相比，Ti-xZr 合金无毒，具有更好的生物力学性能。Ti-45Zr 具有最佳的强度/弹性模量比和成骨活性，因此有望用作牙科植入物。
