Păun Angela Gabriela, Dumitriu Cristina, Ungureanu Camelia, Popescu Simona
Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Gheorghe Polizu 1-7 Street, 011061 Bucharest, Romania.
Materials (Basel). 2023 Aug 26;16(17):5855. doi: 10.3390/ma16175855.
The aim of the present research is to develop a novel hybrid coating for a Ti dental implant that combines nature-inspired biomimetic polymers and TiO nanostructures with an entrapped ZnO antimicrobial agent. ZnO was used in other studies to cover the surface of Ti or Ti-Zr to reduce the need of clinical antibiotics, prevent the onset of peri-implantitis, and increase the success rate of oral clinical implantation. We developed an original coating that represents a promising approach in clinical dentistry. The titanium surface was first anodized to obtain TiO nanotubes (NT). Subsequently, on the NT surface, silk fibroin isolated from Bombyx mori cocoons was deposited as nanofibers using the electrospun technique. For an improved antibacterial effect, ZnO nanoparticles were incorporated in this biopolymer using three different methods. The surface properties of the newly created coatings were assessed to establish how they are influenced by the most important features: morphology, wettability, topography. The evaluation of stability by electrochemical methods in simulated physiological solutions was discussed more in detail, considering that it could bring necessary information related to the behavior of the implant material. All samples had improved roughness and hydrophilicity, as well as corrosion stability (with protection efficiency over 80%). The antibacterial test shows that the functional hybrid coating has good antibacterial activity because it can inhibit the proliferation of up to 53% and up to 55%. All Ti samples with the modified surface have proven superior properties compared with unmodified TiNT, which proved that they have the potential to be used as implant material in dentistry.
本研究的目的是为钛牙科植入物开发一种新型混合涂层，该涂层将受自然启发的仿生聚合物和TiO纳米结构与包裹的ZnO抗菌剂相结合。在其他研究中，ZnO被用于覆盖钛或钛锆的表面，以减少临床抗生素的使用需求，预防种植体周围炎的发生，并提高口腔临床植入的成功率。我们开发了一种原始涂层，这在临床牙科中是一种很有前景的方法。首先对钛表面进行阳极氧化以获得TiO纳米管（NT）。随后，使用静电纺丝技术将从家蚕茧中分离出的丝素蛋白作为纳米纤维沉积在NT表面。为了提高抗菌效果，使用三种不同方法将ZnO纳米颗粒掺入这种生物聚合物中。评估新制备涂层的表面性能，以确定它们如何受到最重要的特征（形态、润湿性、形貌）的影响。考虑到电化学方法在模拟生理溶液中对稳定性的评估可能会带来与植入材料行为相关的必要信息，因此对此进行了更详细的讨论。所有样品的粗糙度和亲水性都有所改善，并且具有腐蚀稳定性（保护效率超过80%）。抗菌测试表明，功能性混合涂层具有良好的抗菌活性，因为它可以分别抑制高达53%和高达55%的增殖。所有表面改性的钛样品与未改性的TiNT相比都具有优异的性能，这证明它们有潜力用作牙科植入材料。
