Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Curr Pharm Des. 2022;28(18):1480-1492. doi: 10.2174/1381612828666220519145859.
Burn injury is considered one of the critical injuries of the skin. According to WHO (World Health Organization), approximately 3,00,000 deaths are caused each year mainly due to fire burns, with additional deaths attributed to heat and other causes of burn e.g., electric devices, chemical materials, radioactive rays, etc. More than 95% of burn injuries occur in developing countries.
Burn injuries have been a prominent topic of discussion in this present era of advancements. Burns is one of the common and devastating forms of trauma. Burn injuries are involved in causing severe damage to skin tissues and various other body parts triggered particularly by fire, blaze, or exposure to chemicals and heated substances. They leave a long-lasting negative impact on the patients in terms of their physical and mental health.
The various methods and bioactive hydrogels, a viable and widely utilised approach for treating chronic wounds, remain a bottleneck. Many traditional approaches such as woven material, conventional antimicrobial agents, hydrogel sheets, and creams are utilised in wound healing. Nowadays, lipid-based nanoparticles, nanofibres systems, and foam-based formulations heal the wound.
The prepared formulation showed wound healing activity when tested on rat model. The nanofibres containing SSD help in the burn-wound healing study on Male Sprague Dawley (SD) rats. The healing effect on rats was examined by western blot analysis, digital camera observation, and histological analyses.
Burn is also considered the most grievous form of trauma. Nowadays, several large and foambased formulations are used in wound healing, which heals the wound better than previously existing formulations and is less prone to secondary infection. Recently, nanofiber delivery systems have piqued the interest of academics as well as researchers because of its unique advantages and features, which include an extraordinarily high surface to volume ratio, a highly porous structure, and tiny pore size.
烧伤被认为是皮肤的重大创伤之一。根据世界卫生组织（WHO）的数据，每年约有 30 万人主要死于火灾烧伤，此外还有因热和其他烧伤原因（如电器、化学物质、放射性射线等）而死亡的人。超过 95%的烧伤发生在发展中国家。
在当今这个进步的时代，烧伤一直是一个备受关注的话题。烧伤是一种常见且严重的创伤形式。烧伤是由火灾、火焰或接触化学物质和加热物质等原因引起的皮肤组织和身体其他部位的严重损伤。它们会对患者的身心健康造成长期的负面影响。
各种方法和生物活性水凝胶是治疗慢性伤口的可行且广泛应用的方法，但仍然存在瓶颈。许多传统方法，如编织材料、传统抗菌剂、水凝胶片和乳膏，都被用于伤口愈合。如今，基于脂质的纳米粒子、纳米纤维系统和泡沫制剂也被用于治疗伤口。
在大鼠模型上进行测试时，所制备的配方显示出了伤口愈合活性。含有 SSD 的纳米纤维有助于对雄性 Sprague Dawley（SD）大鼠进行烧伤伤口愈合研究。通过 Western blot 分析、数码摄像机观察和组织学分析来检查对大鼠的愈合效果。
烧伤也被认为是最严重的创伤形式。如今，几种大型泡沫制剂被用于伤口愈合，其愈合效果优于以前存在的制剂，且不易发生二次感染。最近，纳米纤维输送系统因其独特的优势和特点，引起了学术界和研究人员的兴趣，这些特点包括极高的表面积与体积比、高度多孔的结构和微小的孔径。
