Mawazi Saeid Mezail, Kumar Mohit, Ahmad Noraini, Ge Yi, Mahmood Syed
School of Pharmacy, Management and Science University, Shah Alam 40100, Selangor, Malaysia.
Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda 151001, Punjab, India.
Polymers (Basel). 2024 May 10;16(10):1351. doi: 10.3390/polym16101351.
Chitosan, a versatile biopolymer derived from chitin, has garnered significant attention in various biomedical applications due to its unique properties, such as biocompatibility, biodegradability, and mucoadhesiveness. This review provides an overview of the diverse applications of chitosan and its derivatives in the antibacterial, anticancer, wound healing, and tissue engineering fields. In antibacterial applications, chitosan exhibits potent antimicrobial properties by disrupting microbial membranes and DNA, making it a promising natural preservative and agent against bacterial infections. Its role in cancer therapy involves the development of chitosan-based nanocarriers for targeted drug delivery, enhancing therapeutic efficacy while minimising side effects. Chitosan also plays a crucial role in wound healing by promoting cell proliferation, angiogenesis, and regulating inflammatory responses. Additionally, chitosan serves as a multifunctional scaffold in tissue engineering, facilitating the regeneration of diverse tissues such as cartilage, bone, and neural tissue by promoting cell adhesion and proliferation. The extensive range of applications for chitosan in pharmaceutical and biomedical sciences is not only highlighted by the comprehensive scope of this review, but it also establishes it as a fundamental component for forthcoming research in biomedicine.
壳聚糖是一种由几丁质衍生而来的多功能生物聚合物，因其具有生物相容性、生物可降解性和粘膜粘附性等独特性质，在各种生物医学应用中受到了广泛关注。本文综述了壳聚糖及其衍生物在抗菌、抗癌、伤口愈合和组织工程领域的多种应用。在抗菌应用中，壳聚糖通过破坏微生物膜和DNA表现出强大的抗菌性能，使其成为一种有前景的天然防腐剂和抗细菌感染剂。其在癌症治疗中的作用涉及开发基于壳聚糖的纳米载体用于靶向药物递送，提高治疗效果同时最小化副作用。壳聚糖在伤口愈合中也起着关键作用，通过促进细胞增殖、血管生成和调节炎症反应。此外，壳聚糖在组织工程中作为多功能支架，通过促进细胞粘附和增殖来促进软骨、骨和神经组织等多种组织的再生。壳聚糖在制药和生物医学科学中的广泛应用不仅在本综述的全面范围内得到了突出体现，而且还使其成为生物医学未来研究的基本组成部分。
