Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mental Health Patient Care Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Affect Disord. 2022 Aug 15;311:432-439. doi: 10.1016/j.jad.2022.05.081. Epub 2022 May 19.
The hippocampus and cingulate gyrus are strongly interconnected brain regions that have been implicated in the neurobiology of post-traumatic stress disorder (PTSD). These brain structures are comprised of functionally distinct subregions that may contribute to the expression of PTSD symptoms or associated cardio-metabolic markers, but have not been well investigated in prior studies.
Two divisions of the cingulate cortex (i.e., rostral and caudal) and 11 hippocampal subregions were investigated in 22 male combat-exposed veterans with PTSD and 22 male trauma-exposed veteran controls (TC). Cardio-metabolic measures included cholesterol, body mass index, and mean arterial pressure.
Individuals with PTSD had less caudal cingulate area compared to TC even after controlling for caudal cingulate thickness. Total hippocampus volume was lower in PTSD compared to TC, accounted for by differences in CA1-CA4, granule cell layer of the dentate gyrus, molecular layer, and subiculum. Individuals with PTSD had higher mean arterial pressure compared to TC, which correlated with hippocampus volume only in the PTSD group.
Sample size, cross-sectional analysis, no control for medications and findings limited to males.
These data demonstrate preferential involvement of caudal cingulate area (vs. thickness) and hippocampus subregions in PTSD. The inverse association between hippocampus volume and mean arterial pressure may contribute to accelerated aging known to be associated with PTSD.
海马体和扣带回是相互紧密连接的脑区，它们与创伤后应激障碍（PTSD）的神经生物学有关。这些脑结构由功能上不同的亚区组成，这些亚区可能与 PTSD 症状或相关的心血管代谢标志物的表达有关，但在以前的研究中并未得到充分研究。
在 22 名患有 PTSD 的男性参战老兵和 22 名男性创伤暴露老兵对照者（TC）中研究了扣带皮层的两个分区（即额部和尾部）和 11 个海马亚区。心血管代谢指标包括胆固醇、体重指数和平均动脉压。
即使在控制了尾部扣带厚度后，患有 PTSD 的个体的尾部扣带面积也比 TC 小。与 TC 相比，PTSD 患者的总海马体体积较小，这是由于 CA1-CA4、齿状回颗粒细胞层、分子层和下托的差异所致。与 TC 相比，PTSD 患者的平均动脉压更高，这与 PTSD 组的海马体体积相关。
样本量、横断面分析、未控制药物和发现仅限于男性。
这些数据表明，尾部扣带区（而非厚度）和海马体亚区在 PTSD 中优先受累。海马体体积与平均动脉压之间的反比关系可能与 PTSD 相关的已知加速衰老有关。
