Department of Neurology, Juntendo University School of Medicine, Japan.
Intern Med. 2022 Dec 15;61(24):3723-3727. doi: 10.2169/internalmedicine.8400-21. Epub 2022 May 21.
We experienced a young patient who presented with progressive parkinsonism and cerebellar ataxia. Brain magnetic resonance imaging revealed progressive brain calcification, expanding from the bilateral basal ganglia to the central pons, caused by a delayed reaction to the radiation therapy that she had received to treat craniopharyngioma 14 years earlier. Heterogeneous clinical symptoms due to radiation-induced brain calcification have been described, but parkinsonism has never been reported. While dopamine transporter-single photon emission computed tomography revealed only slight damage to the dopaminergic striatal pathway, the extension of calcification to the periventricular white matter was likely responsible for her parkinsonism.
我们遇到一位年轻患者，表现为进行性帕金森病和小脑共济失调。脑部磁共振成像显示进行性脑钙化，从双侧基底节扩展到中脑，这是由于她 14 年前接受颅咽管瘤放射治疗的延迟反应引起的。已经描述了由于放射诱导脑钙化引起的异质临床症状，但从未报道过帕金森病。虽然多巴胺转运体单光子发射计算机断层扫描仅显示多巴胺能纹状体通路有轻微损伤，但钙化延伸到脑室周围白质可能是导致她帕金森病的原因。
