The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology, Xi'an, 710021, P. R. China.
Chem Asian J. 2022 Jul 15;17(14):e202200284. doi: 10.1002/asia.202200284. Epub 2022 Jun 13.
Nerve agents are a branch of organophosphorus (OP) compounds that chemically cause irreversible inhibition of acetylcholinesterase, thereby failing the hydrolysis of acetylcholine, resulting in severe neurological disease and death in organisms. Thus, the unreasonable use of such compounds threatens public and national security, so it is a high demand to establish portable, low-cost, sensitive, and highly selective methods for their precise detection. In this review, we introduced the recent development of spectroscopy-based optical chemosensors that aimed for the detection of nerve agents, focusing on the progress made in the molecular design, sensing principle and applications. We conclude this Review by highlighting the current challenges associated with the future development and outlook.
神经毒剂是有机磷（OP）化合物的一个分支，它们在化学上会导致乙酰胆碱酯酶不可逆地抑制，从而使乙酰胆碱无法水解，导致生物体出现严重的神经疾病和死亡。因此，不合理地使用这些化合物会威胁到公共和国家安全，因此，建立便携式、低成本、灵敏和高选择性的方法来精确检测这些化合物是非常有必要的。在这篇综述中，我们介绍了基于光谱的光化学传感器在检测神经毒剂方面的最新进展，重点介绍了在分子设计、传感原理和应用方面所取得的进展。我们最后强调了与未来发展和前景相关的当前挑战。
