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[微循环功能障碍研究进展对烧伤休克及烧伤脓毒症休克治疗的启示]

[Inspiration from the research advances in microcirculatory dysfunction to the treatment of burn shock and burn septic shock].

作者信息

Huan J N, Zhang L J

机构信息

Department of Burn and Plastic Surgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen 518035, China.

出版信息

Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2022 May 20;38(5):401-407. doi: 10.3760/cma.j.cn501225-20220323-00082.

Abstract

Microcirculatory dysfunction is an important pathophysiological change of shock. In the last decade, many researches on the mechanism of microcirculatory dysfunction have been involved in areas such as the glycocalyx damage of vascular endothelial cells, macrocirculation- microcirculation discoupling, vascular hyporeactivity, and microcirculation monitoring. Accordingly, this paper discussed how these research findings can be applied to burn patients, with the aim of alerting the clinicians to improving microcirculation, and maintaining hemodynamic coordination during the treatment of burn shock and burn septic shock. In addition, with the development of accurate and reliable microcirculation monitoring techniques, it is necessary to carry out multi-center clinical trials to reveal the clinical significance of target-oriented shock resuscitation protocol combining macrocirculatory and microcirculatory parameters.

摘要

微循环功能障碍是休克重要的病理生理变化。在过去十年中,关于微循环功能障碍机制的许多研究涉及血管内皮细胞糖萼损伤、体循环-微循环解耦联、血管反应性降低以及微循环监测等领域。因此,本文探讨了如何将这些研究结果应用于烧伤患者,旨在提醒临床医生在烧伤休克和烧伤脓毒症休克治疗期间改善微循环并维持血流动力学协调。此外,随着准确可靠的微循环监测技术的发展,有必要开展多中心临床试验以揭示结合体循环和微循环参数的目标导向性休克复苏方案的临床意义。

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Endothelial glycocalyx shedding in patients with burns.烧伤患者的内皮糖萼脱落。
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