Department of Intensive Care, Laboratory of Translational Intensive Care, Erasmus MC, University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
Department of Intensive Care, CHIREC Hospitals and Université Libre de Bruxelles, Bd du Triomphe 201, 1160 Brussels, Belgium.
Crit Care Clin. 2020 Apr;36(2):323-331. doi: 10.1016/j.ccc.2019.11.003. Epub 2020 Jan 22.
Microvascular dysfunction is a frequent complication of many chronic and acute conditions, especially in the critically ill. Moreover, the severity of microvascular alterations is associated with development of organ dysfunction and poor outcome. The complexities and heterogeneity of critical illness, especially in the elderly patient, requires more mechanistically oriented clinical trials that monitor the effectiveness of existing therapies and of those to come. Recent advances in the ability to obtain physiologically based assessments of microcirculatory function at the bedside will make microcirculatory-guided resuscitation a point of care reality.
微血管功能障碍是许多慢性和急性疾病的常见并发症，尤其是在危重病患者中。此外，微血管改变的严重程度与器官功能障碍和不良预后的发展有关。危重病的复杂性和异质性，尤其是在老年患者中，需要更具机制导向的临床试验来监测现有治疗方法和未来治疗方法的效果。目前，在床边获得基于生理学的微血管功能评估的能力取得了新进展，这将使基于微循环的复苏成为一种现实的床边治疗手段。
