Zheng Tianyu, Moustafa Yasmine, Finn Caroline, Scott Sydney, Haase Christopher J, Carpinelli Nathaly A, Osorio Johan S, McKinstry Karl K, Strutt Tara M, Huo Qun
Nano Discovery Inc., 1060 Woodcock Road Suite 131, Orlando, FL, 32803, USA.
Department of Chemistry and NanoScience Technology Center, University of Central Florida, 12424 Research Parkway Suite 400, Orlando, FL, 32826, USA.
Sens Int. 2020;1. doi: 10.1016/j.sintl.2020.100009. Epub 2020 Apr 24.
The immune health of a farm animal can have significant impact on its overall health, welfare and productivity. One of the most vulnerable physiological states for both humans and animals is pregnancy. Many systemic changes correlate with the gravid state, including shifts in the immune system that may impact the ability to respond optimally to pathogen challenge. Because of this, it would be beneficial to be able to monitor the immune health of the pregnant animals closely. Recently, we developed a new nanoparticle-enabled rapid blood test that can detect ongoing immune responses from both laboratory and farm animals. Here, we report that this novel test reveals highly repeatable and acute changes associated with pregnancy and peri-parturition period in laboratory mice and in cattle. We hypothesize that the test score change reflects changes in the immune status of the gravid females related to the humoral immune response. The test is easy to conduct, of low cost, with results obtained in less than 20 min. This rapid test could be potentially used as an onsite test in local farms and small clinics for animal health management.
农场动物的免疫健康会对其整体健康、福利和生产力产生重大影响。人类和动物最脆弱的生理状态之一是怀孕。许多全身变化与妊娠状态相关，包括免疫系统的变化，这可能会影响对病原体挑战做出最佳反应的能力。因此，能够密切监测怀孕动物的免疫健康将是有益的。最近，我们开发了一种新的基于纳米颗粒的快速血液检测方法，该方法可以检测实验室动物和农场动物正在进行的免疫反应。在此，我们报告这种新型检测方法揭示了与实验室小鼠和牛的怀孕及围产期相关的高度可重复和急性变化。我们假设检测分数的变化反映了妊娠雌性动物与体液免疫反应相关的免疫状态变化。该检测方法易于操作，成本低，不到20分钟即可获得结果。这种快速检测方法有可能在当地农场和小型诊所用作动物健康管理的现场检测方法。
