Malinowski A, Szpakowski M, Wilczyński J, Oszukowski P, Puchała B, Włodarczyk B
Department of Obstetrics and Gynecology, Military School of Medicine, Lodz.
Zentralbl Gynakol. 1994;116(11):631-5.
Autoimmune diseases are suspected of causing some cases of recurrent pregnancy loss. We sought serological evidence of such diseases in women with recurrent pregnancy wastage. Antinuclear antibodies were studied administrating indirect immunofluorescence test using HEP-2 cells as targets. We compared the frequency of a low-level antinuclear antibody titers in the 68 women with a history of unexplained recurrent pregnancy losses (group A) to that in 35 with explained repeated pregnancy losses (group B) and 44 healthy pregnant (group C), and 36 healthy nonpregnant women (group D). The frequency of positive ANA tests at a titer of 1:40 or higher was 51.5% in group A, 34.3% in group B, 6.8% in group C and 5.6% in group D. No negative influence on pregnancy outcome was found in case of occurrence of ANA in group A where women were treated with husband's lymphocyte immunisation. The success rate was 78.6% in patients with positive ANA and 62.5% in patients with negative ANA. This study demonstrates a high prevalence of low-titer antinuclear antibody-positive serum in patients with both explained and unexplained pregnancy losses; however, the significance of these findings remains unclear.
自身免疫性疾病被怀疑是导致某些复发性流产病例的原因。我们在复发性流产的女性中寻找此类疾病的血清学证据。使用HEP-2细胞作为靶标，通过间接免疫荧光试验研究抗核抗体。我们比较了68例有不明原因复发性流产病史的女性（A组）、35例有明确原因的复发性流产女性（B组）、44例健康孕妇（C组）和36例健康非孕妇（D组）中低水平抗核抗体滴度的频率。A组中抗核抗体检测滴度为1:40或更高的阳性频率为51.5%，B组为34.3%，C组为6.8%，D组为5.6%。在A组中，接受丈夫淋巴细胞免疫治疗的女性出现抗核抗体时，未发现对妊娠结局有负面影响。抗核抗体阳性患者的成功率为78.6%，抗核抗体阴性患者的成功率为62.5%。这项研究表明，在有明确原因和不明原因流产的患者中，低滴度抗核抗体阳性血清的患病率很高；然而，这些发现的意义仍不明确。
