Polcz Monica, Huston Jessica, Breed Meghan, Case Marisa, Leisy Philip, Schmeckpeper Jeffrey, Vaughn Lexie, Sobey Jenna Helmer, Brophy Colleen, Lindenfeld JoAnn, Hocking Kyle, Alvis Bret
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Medicine, Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Am Heart J Plus. 2022 Mar;15. doi: 10.1016/j.ahjo.2022.100133. Epub 2022 Apr 20.
Clinical symptoms of heart failure commonly include fatigue, edema, and shortness of breath. Unfortunately, clinical monitoring has proven unreliable in predicting congestion and the need for hospitalization. Biosensing wearables have been developed as a potential adjunct to clinical signs and symptoms to detect congestion before it becomes severe thus preventing a heart failure hospitalization.
Clinical signs and symptoms of heart failure will correlate with thoracic bioimpedance measurements (ZOE®) and pulmonary capillary wedge pressure (PCWP).
One hundred and fifty-five subjects undergoing right heart catheterization (RHC) were prospectively enrolled. A Zo value (ohms) was obtained, jugular venous pressure (JVP) was estimated, edema graded, and shortness of breath (SOB) assessed in all subjects. RHC was performed by a scheduled cardiologist per routine. One-way ANOVA was performed to assess the relationship between variables. A Pearson correlation coefficient was used to compare the Zo value and PCWP.
Neither estimated JVP (cmHO) (p = 0.65, n = 110) nor edema scores (p = 0.12, n = 110) demonstrated a significant relationship to PCWP. The presence of subjective SOB also did not demonstrate a significant association with PCWP (p = 0.99, n = 110). There was no correlation between ZOE® and PCWP (r = -0.08, p = 0.56, n = 56).
These findings support the idea that traditional measures for monitoring heart failure patients are limited.
心力衰竭的临床症状通常包括疲劳、水肿和呼吸急促。不幸的是，临床监测已被证明在预测充血情况和住院需求方面并不可靠。生物传感可穿戴设备已被开发出来，作为临床体征和症状的潜在辅助手段，以便在充血变得严重之前检测到它，从而预防心力衰竭住院。
心力衰竭的临床体征和症状将与胸部生物阻抗测量值（ZOE®）和肺毛细血管楔压（PCWP）相关。
前瞻性纳入155名接受右心导管检查（RHC）的受试者。在所有受试者中获取Zo值（欧姆），估计颈静脉压（JVP），对水肿进行分级，并评估呼吸急促（SOB）情况。RHC由指定的心脏病专家按常规进行。进行单因素方差分析以评估变量之间的关系。使用Pearson相关系数比较Zo值和PCWP。
估计的JVP（cmH₂O）（p = 0.65，n = 110）和水肿评分（p = 0.12，n = 110）均未显示与PCWP有显著关系。主观SOB的存在也未显示与PCWP有显著关联（p = 0.99，n = 110）。ZOE®与PCWP之间无相关性（r = -0.08，p = 0.56，n = 56）。
这些发现支持了这样一种观点，即监测心力衰竭患者的传统方法是有限的。
