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胃切除术后重建后网膜自由塑形皮瓣对吻合口和解剖区域的强化作用(OFFROAD):一项回顾性病例对照研究

Omental Free-Shaped Flap Reinforcement on Anastomosis and Dissected Area (OFFROAD) Following Reconstruction after Gastrectomy: A Retrospective Case-Control Study.

作者信息

Park Kyong-Lin, Han Won Ho, Cho Hyunsoon, Ryu Junsun, Kim Young-Woo

机构信息

Center for Gastric Cancer, National Cancer Center, Goyang, Korea.

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang, Korea.

出版信息

J Minim Invasive Surg. 2020 Mar 15;23(1):22-29. doi: 10.7602/jmis.2020.23.1.22.

Abstract

PURPOSE

We devised omental free-shaped flap reinforcement on anastomosis and dissected area (OFFROAD) following reconstruction after gastrectomy. This study aimed to evaluate its safety and early clinical outcomes.

METHODS

One hundred fifty-six patients who underwent totally laparoscopic distal gastrectomy with delta anastomosis from July 2016 to April 2018 were divided into the OFFROAD group (80 patients) and non-OFFROAD group (76 patients). Differences in short-term operative outcomes and surgical complications were compared between the groups. All patients' inflammatory marker levels were measured to monitor flap necrotic change and inflammatory reactions. The clinical features of both groups in terms of anastomotic leakage were transcribed.

RESULTS

Pain score in postoperative day1 was significantly lower in OFFROAD group. The serum WBC count on POD 1 was significantly lower in OG than in NOG. The mean duration of OFFROAD was shorter than five minutes. There were no statistical differences in short-term outcomes and surgical complications between two groups. Anastomotic leakage occurred in three patients in each group and there was no statistical difference in incidence. However, clinical features were notable when anastomotic leakage occurs. Unlike all three patients of non-OFFROAD group manifested every features of peritonitis, each patient of OFFROAD group just manifested only one of the three.

CONCLUSION

This study showed the safety and feasibility of OFFROAD procedure. It might mitigate septic complications when there is an anastomotic leakage. Additional large-scale study is needed to assess the versatile usefulness of OFFROAD aside from its role as a physical barrier.

摘要

目的

我们设计了胃切除术后重建时在吻合口和解剖区域使用网膜自由塑形瓣加固术(OFFROAD)。本研究旨在评估其安全性和早期临床结局。

方法

将2016年7月至2018年4月接受全腹腔镜远端胃切除术并采用三角吻合术的156例患者分为OFFROAD组(80例)和非OFFROAD组(76例)。比较两组短期手术结局和手术并发症的差异。测量所有患者的炎症标志物水平,以监测皮瓣坏死变化和炎症反应。记录两组在吻合口漏方面的临床特征。

结果

OFFROAD组术后第1天的疼痛评分显著更低。OFFROAD组术后第1天的血清白细胞计数显著低于非OFFROAD组。OFFROAD的平均持续时间短于5分钟。两组在短期结局和手术并发症方面无统计学差异。每组均有3例患者发生吻合口漏,发生率无统计学差异。然而,发生吻合口漏时临床特征值得注意。与非OFFROAD组的所有3例患者均表现出腹膜炎的所有特征不同,OFFROAD组的每位患者仅表现出三者之一。

结论

本研究表明了OFFROAD手术的安全性和可行性。当发生吻合口漏时,它可能减轻感染性并发症。除了作为物理屏障的作用外,还需要额外的大规模研究来评估OFFROAD的广泛实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eea0/8985645/04a49bf5b36c/JMIS-23-1-022-f1.jpg

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