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[三角吻合技术在腹腔镜远端胃癌根治术消化道重建中的临床研究]

[Clinical research of delta-shaped anastomosis technology in laparoscopic distal gastrectomy and digestive tract reconstruction].

作者信息

Gao Bo, Huang Qingxing, Dong Jianhong

机构信息

Department of General Surgery, The First Hospital of Yulin, Yulin 719000, China.

Department of Digestive Surgery, Affiliated Tumor Hospital of Shanxi Medical University, Taiyuan 030013, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2017 Jan 25;20(1):73-78.

Abstract

OBJECTIVE

To evaluate the feasibility and safety of the delta-shaped anastomosis in laparoscopic distal gastrectomy and digestive tract reconstruction.

METHODS

Clinical data of 34 gastric cancer patients undergoing laparoscopic distal gastrectomy with the delta-shaped anastomosis for digestive tract reconstruction (delta-shaped group) and 83 gastric cancer patients undergoing laparoscopic distal gastrectomy with Billroth I( for digestive tract reconstruction (Billroth group) by same surgeon team from July 2013 to July 2015 at the Department of Digestive Surgery, Affiliated Tumor Hospital of Shanxi Medical University were retrospectively analyzed. Data of two groups were compared.

RESULT

Age, gender, tumor stage were not significantly different between the two groups(all P>0.05). Operation time of the first 15 cases in delta-shaped group was longer than that in Billroth group [(254.7±35.4) min vs. (177.8±33.0) min, t=11.190, P=0.000], while after above 15 cases, the operation time of delta-shaped group was significantly shorter than that of Billroth group [(142.1±14.6) min vs. (177.8±33.0) min, t=-4.109, P=0.001]. Delta-shaped group had less blood loss during operation [(87.1±36.7) ml vs. (194.0±55.1) ml, t=-10.268, P=0.000], and shorter length of incision [(4.1±0.4) cm vs. (6.1±1.0) cm, t=-10.331, P=0.000] than Billroth group. Compared with Billroth group, delta-shaped group presented faster postoperative bowel function return [(2.8±0.6) d vs. (3.3±0.5) d, t=-3.755, P=0.000], earlier liquid food intake [(7.4±1.5) d vs. (8.1±1.7) d, t=-4.135, P=0.000], earlier ambulation [(4.0±1.6) d vs. (6.8±1.4) d, t=-7.197, P=0.000] and shorter postoperative hospital stay [(12.6±1.9) d vs.(13.6±2.0) d, t=-20.149, P=0.000]. Morbidity of postoperative complication was 5.9%(2/34) in delta-shaped group, including anastomotic fistula in 1 case and incision infection in 1 case, and 6.0%(5/83) in Billroth group, including anastomotic fistula, incision infection, anastomotic stricture and dumping syndrome, without significant difference(P>0.05). Difference value of total protein and albumin between pre-operation and post-operation, and average decreased value of total protein, albumin, body weight between pre-operation and postoperative 6-month were not significantly different between two groups(all P>0.05). As for patients with BMI > 25 kg/m, compared to Billroth group, delta-shaped group presented less blood loss during operation [(94.1±36.7) ml vs. (203.0±55.1) ml, t=-10.268, P=0.000], lower injective dosage of postoperative analgesics [(1.9±1.1) ampule vs.(3.3±2.0) ampule, t=-2.188, P=0.032], faster intestinal recovery [(2.9±0.7) d vs. (3.2±0.9) d, t=-3.755, P=0.009], shorter hospital stay [(10.5±1.2) d vs. (11.7±1.5) d, t=-2.026, P=0.004], and lower morbidity of postoperative complication [7.1%(1/14) vs. 13.6%(3/22), χ=4.066, P=0.031].

CONCLUSION

In laparoscopic distal gastrectomy and digestive tract reconstruction, the delta-shaped anastomosis is safe and feasible, especially suitable for obese patients.

摘要

目的

评估三角形吻合术在腹腔镜远端胃癌根治术及消化道重建中的可行性及安全性。

方法

回顾性分析2013年7月至2015年7月于山西医科大学附属肿瘤医院胃肠外科,由同一手术团队完成的34例行腹腔镜远端胃癌根治术并采用三角形吻合术进行消化道重建的胃癌患者(三角形组)和83例行腹腔镜远端胃癌根治术并采用毕Ⅰ式进行消化道重建的胃癌患者(毕Ⅰ式组)的临床资料,比较两组数据。

结果

两组患者的年龄、性别、肿瘤分期差异均无统计学意义(均P>0.05)。三角形组前15例患者的手术时间长于毕Ⅰ式组[(254.7±35.4)分钟对(177.8±33.0)分钟,t=11.190,P=0.000],而15例之后,三角形组的手术时间显著短于毕Ⅰ式组[(142.1±14.6)分钟对(177.8±33.0)分钟,t=-4.109,P=0.001]。三角形组术中出血量少于毕Ⅰ式组[(87.1±36.7)毫升对(194.0±55.1)毫升,t=-10.268,P=0.000],切口长度短于毕Ⅰ式组[(4.1±0.4)厘米对(6.1±1.0)厘米,t=-10.331,P=0.000]。与毕Ⅰ式组相比,三角形组术后胃肠功能恢复更快[(2.8±0.6)天对(3.3±0.5)天,t=-3.755,P=0.000],开始进流食时间更早[(7.4±1.5)天对(8.1±1.7)天,t=-4.135,P=0.000],开始下床活动时间更早[(4.0±1.6)天对(6.8±1.4)天,t=-7.197,P=0.000],术后住院时间更短[(12.6±1.9)天对(13.6±2.0)天,t=-20.149,P=0.000]。三角形组术后并发症发生率为5.9%(2/34),包括吻合口漏1例、切口感染1例;毕Ⅰ式组术后并发症发生率为6.0%(5/83),包括吻合口漏、切口感染、吻合口狭窄及倾倒综合征,两组差异无统计学意义(P>0.05)。两组患者术前、术后总蛋白及白蛋白差值,术前、术后6个月总蛋白、白蛋白及体重平均下降值差异均无统计学意义(均P>0.05)。对于BMI>25kg/m的患者,与毕Ⅰ式组相比,三角形组术中出血量更少[(94.1±36.7)毫升对(203.0±55.1)毫升,t=-10.268,P=0.000],术后镇痛药注射剂量更低[(1.9±1.1)支对(3.3±2.0)支,t=-2.188,P=0.032],肠道恢复更快[(2.9±0.7)天对(3.2±0.9)天,t=-3.755,P=0.009],住院时间更短[(10.5±1.2)天对(11.7±1.5)天,t=-2.026,P=0.004],术后并发症发生率更低[7.1%(1/14)对13.6%(3/22),χ=4.066,P=0.031]。

结论

在腹腔镜远端胃癌根治术及消化道重建中,三角形吻合术安全可行,尤其适用于肥胖患者。

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