Liu Wenlong, Zeng Qingxiang, Zeng Yinhui, Tang Yiquan, Luo Renzhong
Department of Otolaryngology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No. 9, Jinsui Road, Guangzhou, China.
World Allergy Organ J. 2022 May 7;15(5):100650. doi: 10.1016/j.waojou.2022.100650. eCollection 2022 May.
Allergic rhinitis (AR) is a frequent inflammatory disorder of the upper respiratory tract, which has complex patterns of inheritance. Accumulating evidence has shown the key roles of DNA damage in inflammatory diseases, and the base excision repair (BER) is the primary pathway responsible for DNA repair during inflammation.
Here, we performed a case-control study to investigate the associations between 20 potentially functional single nucleotide polymorphisms (SNPs) in 6 BER pathway genes (, , , , , and ) and AR susceptibility in 508 AR cases and 526 controls which originated in China. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for evaluating the association strength.
We found that rs1052133 G > C and rs2682585 G > A polymorphisms were associated with decreased AR risk (adjusted OR = 0.67, 95% CI = 0.47-0.94, = 0.022; and adjusted OR = 0.21, 95% CI = 0.06-0.79, = 0.022, respectively). Stratification analysis suggested that: rs1052133 GC/CC genotype reduced AR risk in subjects among following subgroups: age ≤60 months, females, and moderate AR; rs2682585 GG genotype decreased AR risk in subjects age >60 months, and rs1052536 TT genotype increased AR risk in subjects of severe AR.
Our findings indicated that the genetic variants of , , and genes might affect AR susceptibility in the Chinese population, which will provide novel insight into the genetic underpinnings of AR from the DNA damage level.
变应性鼻炎（AR）是上呼吸道常见的炎症性疾病，具有复杂的遗传模式。越来越多的证据表明DNA损伤在炎症性疾病中起关键作用，而碱基切除修复（BER）是炎症期间负责DNA修复的主要途径。
在此，我们进行了一项病例对照研究，以调查6个BER途径基因（、、、、和）中的20个潜在功能性单核苷酸多态性（SNP）与508例AR病例和526例中国对照者的AR易感性之间的关联。计算比值比（OR）和95%置信区间（CI）以评估关联强度。
我们发现rs1052133 G>C和rs2682585 G>A多态性与AR风险降低相关（校正OR=0.67，95%CI=0.47-0.94，=0.022；校正OR=0.21，95%CI=0.06-0.79，=0.022）。分层分析表明：rs1052133 GC/CC基因型在以下亚组受试者中降低AR风险：年龄≤60个月、女性和中度AR；rs2682585 GG基因型在年龄>60个月的受试者中降低AR风险，而rs1052536 TT基因型在重度AR受试者中增加AR风险。
我们的研究结果表明，、和基因的遗传变异可能影响中国人群的AR易感性，这将从DNA损伤水平为AR的遗传基础提供新的见解。
