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多组学分析为中国长江流域养殖和野生[具体物种未给出]中肠道微生物群、脂肪酸代谢和免疫反应之间的相互作用提供了新见解。

Multi-Omics Analysis Provides New Insights into the Interplay Between Gut Microbiota, Fatty Acid Metabolism, and Immune Response in Cultured and Wild from the Yangtze River Area in China.

作者信息

Yang Chang, Liu Kai, Deng Yanmin, Wang Qianhui, Cao Shiqian, Zhou Qunlan

机构信息

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214128, China.

Freshwater Fisheries Research Center, Chinese Academy of Fishery Science, Wuxi 214081, China.

出版信息

Microorganisms. 2025 Jul 21;13(7):1711. doi: 10.3390/microorganisms13071711.

DOI:10.3390/microorganisms13071711
PMID:40732220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12300613/
Abstract

To elucidate the interactions among fatty acid metabolism, immune status, and gut microbiota, both cultured and wild from the Yangtze River were examined in China. The results demonstrated that wild exhibited markedly higher lipid and docosahexaenoic acid (DHA) contents, a greater ratio of total ω-3 PUFAs to total ω-6 PUFAs, and more active antioxidant enzymes compared to cultured . However, the shear force, water-holding capacity, and total n-6 PUFA content were lower in wild . Transcriptome analysis revealed distinct gene expression patterns: wild upregulated immune-related genes, while cultured downregulated genes related to fatty acid metabolism. Significant differences were observed in alpha and beta diversity between cultured and wild groups. LEfSe analysis identified , , and as biomarkers for cultured , while eight genera, including and , were predominant in wild . Modular analysis identified five modules linked to immune functions and fatty acid metabolism. , , and were dominant in the first two modules, with and as key regulators of fatty acid metabolism and immune processes. These differences, likely due to gut microbiota variations, provide insights for nutritional studies.

摘要

为阐明脂肪酸代谢、免疫状态和肠道微生物群之间的相互作用，在中国对长江流域养殖的和野生的[具体物种未明确]进行了研究。结果表明，与养殖的[具体物种未明确]相比，野生的[具体物种未明确]呈现出显著更高的脂质和二十二碳六烯酸（DHA）含量、总ω-3多不饱和脂肪酸与总ω-6多不饱和脂肪酸的比例更高，以及抗氧化酶活性更强。然而，野生的[具体物种未明确]的剪切力、持水能力和总n-6多不饱和脂肪酸含量较低。转录组分析揭示了不同的基因表达模式：野生的[具体物种未明确]上调了免疫相关基因，而养殖的[具体物种未明确]下调了与脂肪酸代谢相关的基因。在养殖组和野生组之间观察到α和β多样性存在显著差异。线性判别分析效应大小（LEfSe）分析确定[具体物种未明确]、[具体物种未明确]和[具体物种未明确]为养殖的[具体物种未明确]的生物标志物，而包括[具体物种未明确]和[具体物种未明确]在内的八个属在野生的[具体物种未明确]中占主导地位。模块分析确定了五个与免疫功能和脂肪酸代谢相关的模块。[具体物种未明确]、[具体物种未明确]和[具体物种未明确]在前两个模块中占主导地位，[具体物种未明确]和[具体物种未明确]作为脂肪酸代谢和免疫过程的关键调节因子。这些差异可能归因于肠道微生物群的变化，为[具体物种未明确]营养研究提供了见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/effb393fe521/microorganisms-13-01711-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/401781b96c29/microorganisms-13-01711-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/837d8d5b2304/microorganisms-13-01711-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/e58665ed95cb/microorganisms-13-01711-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/da4aa3267410/microorganisms-13-01711-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/ff3b8b86d865/microorganisms-13-01711-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/effb393fe521/microorganisms-13-01711-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/401781b96c29/microorganisms-13-01711-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/5d8fdf566ed7/microorganisms-13-01711-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/4783cac24518/microorganisms-13-01711-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/e41942de3808/microorganisms-13-01711-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/70ead9653efc/microorganisms-13-01711-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/b7e12269acfd/microorganisms-13-01711-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/837d8d5b2304/microorganisms-13-01711-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/e58665ed95cb/microorganisms-13-01711-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/da4aa3267410/microorganisms-13-01711-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/ff3b8b86d865/microorganisms-13-01711-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ad/12300613/effb393fe521/microorganisms-13-01711-g011.jpg

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