Abbasifard Mitra, Kazemi Arababadi Mohammad, Bahrehmand Fatemeh, Bazmandegan Gholamreza, Shabani Shahrbabaki Ziba, Kamiab Zahra
Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences Rafsanjan, Iran.
Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences Rafsanjan, Iran.
Am J Clin Exp Immunol. 2022 Apr 15;11(2):28-33. eCollection 2022.
Cytokine storm is a main complication in the hospitalized patients, who are infected with the novel coronavirus (COVID-19). The pro-inflammatory cytokines are the main causes of the cytokine storm, however, the roles played by IL-17A, IL-23 and CCL3 are yet to be clarified completely. This prospective study was aimed to explore serum levels of these cytokines in the hospitalized patients infected by COVID-19. Serum levels of IL-17A, IL-23 and CCL3 were measured in 30 COVID-19 infected patients in parallel with 30 healthy controls using ELISA technique. Although serum levels of IL-17A, IL-23 and CCL3 did not alter in the patients in comparison to healthy controls, male patients had higher serum levels of IL-23 than women. Hypertension, type 2 diabetes, lung involvement and age did not affect serum levels of IL-17A, IL-23 and CCL3 in the patients. It appears that IL-17A, IL-23 and CCL3 do not participate in the pro-inflammatory responses in Iranian hospitalized COVID-19 infected patients. However, the gender can be considered as a risk factor for production of more IL-23, which needs to be explored further.
细胞因子风暴是新型冠状病毒（COVID-19）感染住院患者的主要并发症。促炎细胞因子是细胞因子风暴的主要原因，然而，白细胞介素-17A（IL-17A）、白细胞介素-23（IL-23）和趋化因子配体3（CCL3）所起的作用尚未完全阐明。这项前瞻性研究旨在探讨COVID-19感染住院患者血清中这些细胞因子的水平。采用酶联免疫吸附测定（ELISA）技术，对30例COVID-19感染患者和30例健康对照者的血清IL-17A、IL-23和CCL3水平进行了平行检测。尽管与健康对照者相比，患者血清中IL-17A、IL-23和CCL3水平没有变化，但男性患者血清IL-23水平高于女性。高血压、2型糖尿病、肺部受累情况和年龄对患者血清IL-17A、IL-23和CCL3水平没有影响。看来，IL-17A、IL-23和CCL3在伊朗COVID-19感染住院患者的促炎反应中不发挥作用。然而，性别可被视为产生更多IL-23的一个风险因素，这有待进一步研究。
