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用于筛选针对神经退行性疾病的不同药物和植物提取物的铜结合分子的光谱、电化学和生物学分析

Spectroscopic, Electrochemical, and Biological Assays of Copper-Binding Molecules for Screening of Different Drugs and Plant Extracts against Neurodegenerative Disorders.

作者信息

Brinvillier David, Barrast Melissa, Couderc-Murillo Petra, Bono-Yagüe José, Rousteau Alain, Gómez Escribano Ana Pilar, Palmeira-Mello Marcos V, Doménech-Carbó Antonio, Passe-Coutrin Nady, Sylvestre Muriel, Vázquez-Manrique Rafael P, Cebrián-Torrejón Gerardo

机构信息

COVACHIM-M2E Laboratory EA 3592, UFR SEN, Department of Chemistry, University of the French West Indies, Fouillole Campus, Pointe-à-Pitre Cedex 97157, France.

UA, UMR EcoFoG, CNRS, Cirad, INRA, Université des Antilles, Université de Guyane, Université des Antilles, Pointe-à-Pitre 97159, France.

出版信息

ACS Omega. 2022 May 4;7(19):16260-16269. doi: 10.1021/acsomega.1c03378. eCollection 2022 May 17.

DOI:10.1021/acsomega.1c03378
PMID:35601340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9118385/
Abstract

Neurodegenerative disorders, caused by prone-to-aggregation proteins, such as Alzheimer disease or Huntington disease, share other traits such as disrupted homeostasis of essential metal ions, like copper. In this context, in an attempt to identify Cu chelating agents, we study several organic compounds (ethylenediaminetetraacetic acid, phenylenediamine, metformin, salicylate, and trehalose) and organic extracts obtained from L., which has been used in Ayurvedic therapies and presented a broad spectrum of biological properties. For this purpose, UV-visible spectroscopy analysis and electrochemical measurements were performed. Further, biological assays were performed in models of polyQ toxicity, in an attempt to obtain better insights on neurodegenerative disorders.

摘要

由易聚集蛋白引起的神经退行性疾病，如阿尔茨海默病或亨廷顿病，还具有其他特征，如必需金属离子（如铜）的体内平衡紊乱。在此背景下，为了鉴定铜螯合剂，我们研究了几种有机化合物（乙二胺四乙酸、苯二胺、二甲双胍、水杨酸盐和海藻糖）以及从L.中提取的有机提取物，L.已被用于阿育吠陀疗法并具有广泛的生物学特性。为此，进行了紫外可见光谱分析和电化学测量。此外，在多聚谷氨酰胺毒性模型中进行了生物学测定，以期更深入地了解神经退行性疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/032ae9a79747/ao1c03378_0002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/771ffc7f0e48/ao1c03378_0008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/032ae9a79747/ao1c03378_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/73a8239b5252/ao1c03378_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/9bd6d383f5c9/ao1c03378_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/1ae98703cc78/ao1c03378_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/220f32c8b809/ao1c03378_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/c338f80d10ac/ao1c03378_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/771ffc7f0e48/ao1c03378_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/aefd59d2c042/ao1c03378_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f80/9118385/032ae9a79747/ao1c03378_0002.jpg

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