Njom Nlend Anne Esther
Research Department, Health Ebene Consulting, Yaoundé, Cameroon.
Int J Womens Health. 2022 May 13;14:697-703. doi: 10.2147/IJWH.S330715. eCollection 2022.
Despite critical progress registered in the reduction of mother to child transmission (MTCT) of HIV worldwide, transmission through breastfeeding still contributes to almost 50% of pediatric HIV infections recorded every year. In this short narrative review, after development of an extensive background on HIV and breastfeeding, some directions are suggested to address the key bottlenecks. Specifically, reinforcing the prevention of MTCT through breastfeeding (BF) in order to move towards elimination of MTCT prior to 2030 may require, among others strategies: tracking all women of child bearing age through HIV testing, improving testing and retesting of women during pregnancy and breastfeeding, strengthening adherence on antiretroviral therapy (ART) among pregnant and lactating women, ensuring continuum and retention in care of mother and baby-pairs up to 24 months, switching ART in non-viral suppressed mothers after improvement of adherence counseling. In addition, due to the burden of seroconversion during pregnancy or thereafter through BF, pre-exposure prophylaxis (PreP) for most at risk women should be implemented urgently. The opportunity to extend the infant prophylaxis to the whole lactating period should be assessed to address residual transmission amongst viral suppressed mothers.
尽管全球在减少母婴传播艾滋病毒(MTCT)方面取得了重大进展,但通过母乳喂养传播的情况仍占每年记录的儿童艾滋病毒感染病例的近50%。在这篇简短的叙述性综述中,在阐述了关于艾滋病毒和母乳喂养的广泛背景后,提出了一些应对关键瓶颈问题的方向。具体而言,为了在2030年前实现消除母婴传播,加强通过母乳喂养预防母婴传播(BF)可能需要采取多种策略,包括:通过艾滋病毒检测追踪所有育龄妇女,改善孕期和哺乳期妇女的检测与复测,加强孕妇和哺乳期妇女对抗逆转录病毒疗法(ART)的依从性,确保母婴在24个月内持续接受护理并保持随访,在改善依从性咨询后为病毒未被抑制的母亲更换抗逆转录病毒疗法。此外,鉴于孕期或之后通过母乳喂养发生血清转化的负担,应紧急为高危女性实施暴露前预防(PreP)。应评估将婴儿预防措施扩展至整个哺乳期的机会,以解决病毒被抑制的母亲中的残余传播问题。