Jia Xinlin, Ma Junping, Chen Xuzhuo, Li Wentao, Zhou Xianhao, Lei Bo, Zhao Xin, Mao Yuanqing
Shanghai Key Laboratory of Orthopedic Implant, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China.
Mater Today Bio. 2022 May 6;15:100277. doi: 10.1016/j.mtbio.2022.100277. eCollection 2022 Jun.
Current treatments of osteoarthritis, such as oral medication and intra-articular injections, only provided temporary relief from pain and achieved limited advance in inhibiting progression. The development of new treatments is hindered by the complicated and unclear pathological mechanisms. Oxidative stress and immune inflammation are believed to be the important factors in the induction and progression of osteoarthritis. Herein, this work presents a bioactive material strategy to treat osteoarthritis, based on the FPSOH matrixgel with robust anti-inflammatory activity through inhibiting the oxidative stress and nuclear factor kappa B signaling, preventing the metalloproteinase, as well as inducing M2 polarization of macrophage, thereby providing immune regulation of synovial macrophages and suppressing the progression of synovitis and osteoarthritis. experiments demonstrated that FPSOH hydrogel can prevent papain-induced osteoarthritis and its progression, and provide dual protection for cartilage and synovium, as compared with commercial sodium hyaluronate.
骨关节炎的现有治疗方法，如口服药物和关节内注射，只能暂时缓解疼痛，在抑制疾病进展方面进展有限。新治疗方法的开发受到复杂且不明的病理机制的阻碍。氧化应激和免疫炎症被认为是骨关节炎诱导和进展的重要因素。在此，本研究提出了一种治疗骨关节炎的生物活性材料策略，基于具有强大抗炎活性的FPSOH基质凝胶，通过抑制氧化应激和核因子κB信号传导、抑制金属蛋白酶以及诱导巨噬细胞的M2极化，从而实现对滑膜巨噬细胞的免疫调节，抑制滑膜炎和骨关节炎的进展。实验表明，与市售透明质酸钠相比，FPSOH水凝胶可以预防木瓜蛋白酶诱导的骨关节炎及其进展，并为软骨和滑膜提供双重保护。
