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鉴定参与HIV-1和SIV直肠传播的CX3CR1单核吞噬细胞亚群。

Identification of CX3CR1 mononuclear phagocyte subsets involved in HIV-1 and SIV colorectal transmission.

作者信息

Cavarelli Mariangela, Foglieni Chiara, Hantour Naima, Schorn Tilo, Ferrazzano Antonello, Dispinseri Stefania, Desjardins Delphine, Elmore Ugo, Dereuddre-Bosquet Nathalie, Scarlatti Gabriella, Le Grand Roger

机构信息

Université Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-immune, Hematological and Bacterial Diseases (IMVA-HB/IDMIT), 18, route du Panorama 92265 Fontenay-aux-Roses, Le Kremlin-Bicêtre, France.

Myocardial Diseases and Atherosclerosis Unit, IRCCS Ospedale San Raffaele, Milan, Italy.

出版信息

iScience. 2022 May 2;25(6):104346. doi: 10.1016/j.isci.2022.104346. eCollection 2022 Jun 17.

DOI:10.1016/j.isci.2022.104346
PMID:35601921
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9117554/
Abstract

The difficulty to unambiguously identify the various subsets of mononuclear phagocytes (MNPs) of the intestinal has hindered our understanding of the initial events occurring after mucosal exposure to HIV-1. Here, we compared the composition and function of MNP subsets at steady-state and following and viral exposure in human and macaque colorectal tissues. Combined evaluation of CD11c, CD64, CD103, and CX3CR1 expression allowed to differentiate MNPs subsets common to both species. Among them, CD11c CX3CR1 cells expressing CCR5 migrated inside the epithelium following and exposure of colonic tissue to HIV-1 or SIV. In addition, the predominant population of CX3CR1 macrophages present at steady-state partially shifted to CX3CR1 macrophages as early as three days following SIV rectal challenge of macaques. Our analysis identifies CX3CR1 MNPs as novel players in the early events of HIV-1 and SIV colorectal transmission.

摘要

明确识别肠道单核吞噬细胞（MNP）的各个亚群存在困难，这阻碍了我们对黏膜暴露于HIV-1后发生的初始事件的理解。在此，我们比较了人类和猕猴结肠组织在稳态以及模拟和真实病毒暴露后MNP亚群的组成和功能。联合评估CD11c、CD64、CD103和CX3CR1的表达能够区分两种物种共有的MNP亚群。其中，表达CCR5的CD11c⁺CX3CR1⁺细胞在结肠组织暴露于HIV-1或SIV后迁移至上皮内。此外，在稳态时占主导的CX3CR1⁺巨噬细胞群体在猕猴经直肠感染SIV后最早三天就部分转变为CX3CR1⁻巨噬细胞。我们的分析确定CX3CR1⁺MNP是HIV-1和SIV结肠直肠传播早期事件中的新参与者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/77207f2cacc8/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/2fca1dbfed6f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/39bfd04ecc32/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/b89b3c992814/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/1ae817952346/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/1dba66751860/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/b89f6cdfed13/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/9956b240f5c8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/77207f2cacc8/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/2fca1dbfed6f/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/39bfd04ecc32/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/b89b3c992814/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/1ae817952346/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/1dba66751860/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/b89f6cdfed13/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/9956b240f5c8/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a2ad/9117554/77207f2cacc8/gr7.jpg

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