Christopher Paulus Mario, Kristiani Erna
MD, Faculty of Medicine, Pelita Harapan University, Jenderal Sudirman Lippo Karawaci Boulevard Road, Tangerang, Banten, 15811, Indonesia.
MD, Anatomical Pathologist, Department of Anatomical Pathology, Faculty of Medicine, Pelita Harapan University, Banten, 15811, Indonesia.
Germs. 2022 Mar 31;12(1):118-123. doi: 10.18683/germs.2022.1314. eCollection 2022 Mar.
Ecthyma gangrenosum (EG) is a rare cutaneous manifestation commonly associated with infection in immunocompromised individuals. Additionally, different bacterial and fungal pathogens have also been identified. However, co-infection on EG lesions has never been reported before.
We present the case of a seven-year-old female Asian patient who initially was diagnosed with febrile neutropenia. Initially, on the sixth day of admission, dermatological status revealed multiple painless erythematous macules on the face and arms together with persistent fever followed by evolution to multiple black, deep-seated, and large central eschars and early identification of in the blood culture. Further evaluation revealed the development of EG with XDR and spp. isolated from the samples harvested intraoperatively.
Specific identification of etiological agents will serve its importance for early diagnosis, aggressive antibiotic treatment, and/or surgical intervention to improve the prognosis.
坏疽性脓皮病(EG)是一种罕见的皮肤表现,通常与免疫功能低下个体的感染有关。此外,还发现了不同的细菌和真菌病原体。然而,此前从未有过EG病变合并感染的报道。
我们报告一例7岁亚洲女性患者,最初被诊断为发热性中性粒细胞减少症。入院第6天,皮肤科检查发现面部和手臂有多个无痛性红斑丘疹,伴有持续发热,随后发展为多个黑色、深部、大的中央焦痂,并在血培养中早期鉴定出[病原体名称未明确]。进一步评估显示发生了EG,从术中采集的样本中分离出广泛耐药[病原体名称未明确]和[病原体名称未明确]菌种。
病原体的特异性鉴定对于早期诊断、积极的抗生素治疗和/或手术干预以改善预后具有重要意义。