Ilonen J, Cantell K, Reunanen M, Panelius M, Ziola B, Lund G, Salmi A
J Clin Lab Immunol. 1987 Jan;22(1):41-7.
A 171/2-year-old male subacute sclerosing panencephalitis patient underwent a disease relapse after an 8 year remission. A total of 14 paired peripheral blood/cerebrospinal fluid specimens were obtained during this relapse. These specimens were tested for 13 parameters of non-specific or measles virus-specific cell-mediated and humoral immunity. There was a rapid and significant fluctuation in all of these tests. Total loss of measles-specific T cells response was found during the relapse. The response re-appeared and measles-specific antibodies increased significantly later on. The results suggest that measles virus infection was reactivated in this patient and that the observed immunological changes could at least partially be explained by this.
一名17岁半的亚急性硬化性全脑炎男性患者在缓解8年后病情复发。在此次复发期间共采集了14对外周血/脑脊液样本。对这些样本进行了13项非特异性或麻疹病毒特异性细胞介导和体液免疫参数的检测。所有这些检测结果都出现了快速且显著的波动。在复发期间发现麻疹特异性T细胞反应完全丧失。之后反应重新出现，麻疹特异性抗体显著增加。结果表明该患者体内麻疹病毒感染被重新激活，观察到的免疫变化至少部分可以由此解释。
