de Souza Jose Neto Ribeiro, de Castro Fernanda de Oliveira Feitosa, de Souza Camila Lemes, El Cheikh Mikhael Romanholo, Ramos Hugo Valter Lisboa, da Fonseca Simone Gonçalves, Costa Claudiney Candido
Department of Otorhinolaryngology, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Institute of Tropical Pathology and Public Health, Universidade Federal de Goiás, Goiânia, GO, Brazil.
Int Arch Otorhinolaryngol. 2021 Aug 19;26(2):e208-e212. doi: 10.1055/s-0041-1730301. eCollection 2022 Apr.
Palatine and pharyngeal tonsils are the first line of defense against pathogens. Clinically, two alterations may require surgical removal of the tonsils: hypertrophy and recurrent tonsillitis. The two conditions probably result from a dysfunction of the immune system. To evaluate possible differences in the plasma levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in patients submitted to adenotonsillectomy. Prospective, longitudinal study with 25 children undergoing adenotonsillectomy separated into 3 different groups: recurrent tonsillitis (RT), composed of 7 patients; recurrent hypertrophy tonsillitis (RTTH), with 8 patients; and the tonsillar hypertrophy (TH) group, with 10 patients. Ten healthy control children (SD) were also included in the study. Peripheral blood was collected, and plasma was separated to measure the levels of TNF-α, IL-6, and IL-10. The Mann-Whitney test was used for statistical analysis. The plasma level of IL-6 was higher in the RT ( = 0.0394) and TH ( = 0.0009) groups, compared with the control group. The TH group also had higher levels of IL-6 than the RT group ( = 0.039). The IL-6/IL-10 ratio was higher in the RT ( = 0.029) and TH ( = 0.0005) groups compared with the control group. Between the RT and RTTH groups, the IL-6/IL-10 ratio was higher in the RT group, with a statistically significant difference ( = 0.0091). Patients with a history of chronic tonsillitis had higher levels of IL-6, compared with the control group.
腭扁桃体和咽扁桃体是抵御病原体的第一道防线。临床上，有两种情况可能需要手术切除扁桃体：肥大和复发性扁桃体炎。这两种情况可能是免疫系统功能障碍所致。
为了评估接受腺扁桃体切除术患者血浆中肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）水平的可能差异。
对25例接受腺扁桃体切除术的儿童进行前瞻性纵向研究，将其分为3个不同组：复发性扁桃体炎（RT）组，7例患者；复发性肥大性扁桃体炎（RTTH）组，8例患者；扁桃体肥大（TH）组，10例患者。另外10名健康对照儿童（SD）也纳入研究。采集外周血，分离血浆以测量TNF-α、IL-6和IL-10水平。采用曼-惠特尼检验进行统计分析。
与对照组相比，RT组（P = 0.0394）和TH组（P = 0.0009）的IL-6血浆水平更高。TH组的IL-6水平也高于RT组（P = 0.039）。与对照组相比，RT组（P = 0.029）和TH组（P = 0.0005）的IL-6/IL-10比值更高。在RT组和RTTH组之间，RT组的IL-6/IL-10比值更高，差异有统计学意义（P = 0.0091）。
与对照组相比，有慢性扁桃体炎病史的患者IL-6水平更高。
