de Oliveira Caio Marcio Barros, Sakata Rioko Kimiko, Issy Adriana Machado, Gerola Luis Roberto, Salomão Reynaldo
Disciplina de Anestesiologia, Dor e Terapia Intensiva of Escola Paulista de Medicina da Universidade Federal de São Paulo (EPM/UNIFESP), SP, Brazil.
Rev Bras Anestesiol. 2011 Mar-Apr;61(2):255-9, 260-5, 137-42. doi: 10.1016/S0034-7094(11)70029-0.
Cytokines are necessary for the inflammatory response, favoring proper wound healing. However, exaggerated proinflammatory cytokine production can manifest systemically as hemodynamic instability or metabolic derangements. The objective of this review was to describe the effects of cytokines in pain.
This article reviews the effects of cytokines in pain. In diseases with acute or chronic inflammation, cytokines can be recognized by neurons and used to trigger several cell reactions that influence the activity, proliferation, and survival of immune cells, as well as the production and activity of other cytokines. Cytokines can be proinflammatory and anti-inflammatory. Proinflammatory cytokines are related with the pathophysiology of pain syndromes. Cells that secrete proinflammatory (IL-1, IL-2, IL-6, IL-7, and TNF) and anti-inflammatory (IL-4, IL-10, IL-13, and TGFβ) cytokines, the functions of each cytokine, and the action of those compounds on pain processing, have been described.
Cytokines have an important role in pain through different mechanisms in several sites of pain transmission pathways.
细胞因子对于炎症反应是必需的，有助于伤口正常愈合。然而，促炎细胞因子产生过多可在全身表现为血流动力学不稳定或代谢紊乱。本综述的目的是描述细胞因子在疼痛中的作用。
本文综述了细胞因子在疼痛中的作用。在急性或慢性炎症性疾病中，细胞因子可被神经元识别，并用于触发多种细胞反应，这些反应会影响免疫细胞的活性、增殖和存活，以及其他细胞因子的产生和活性。细胞因子可分为促炎细胞因子和抗炎细胞因子。促炎细胞因子与疼痛综合征的病理生理学相关。已描述了分泌促炎（白细胞介素-1、白细胞介素-2、白细胞介素-6、白细胞介素-7和肿瘤坏死因子）和抗炎（白细胞介素-4、白细胞介素-10、白细胞介素-13和转化生长因子β）细胞因子的细胞、每种细胞因子的功能以及这些化合物在疼痛处理中的作用。
细胞因子通过疼痛传递途径多个部位的不同机制在疼痛中发挥重要作用。
