Schnaid E, Lamprey J M, Viljoen M J, Joffe B I, Seftel H C
J Trauma. 1987 Mar;27(3):309-11. doi: 10.1097/00005373-198703000-00015.
Free fatty acids (FFA) are believed to play a role in the genesis of the fat embolism syndrome (FES). Levels of plasma FFA, glucose, insulin, and the stress hormones cortisol, growth hormone, prolactin, glucagon, and catecholamines were measured on admission to hospital in: a) 14 patients with long bone fractures at risk of developing FES, b) 14 patients with soft-tissue injuries of comparable severity, and c) 20 healthy fasting subjects. The findings were similar in both groups of injured patients and in keeping with the hormonal and substrate responses to the stress of trauma; plasma FFA levels were raised but in neither group was the rise pronounced. Plasma FFA levels of the fracture patients were only moderately higher than the values of the healthy fasting subjects. These findings suggest that mobilized FFA from peripheral adipose tissue are not important in the genesis of the FES, but do not exclude a role for FFA derived mainly from hydrolysis of triglyceride emboli in the lung.
游离脂肪酸（FFA）被认为在脂肪栓塞综合征（FES）的发病机制中起作用。在以下人群入院时测定了血浆FFA、葡萄糖、胰岛素以及应激激素皮质醇、生长激素、催乳素、胰高血糖素和儿茶酚胺的水平：a）14例有发生FES风险的长骨骨折患者，b）14例具有相当严重程度软组织损伤的患者，以及c）20名健康的空腹受试者。两组受伤患者的结果相似，且与创伤应激时的激素和底物反应一致；血浆FFA水平升高，但两组中升高均不明显。骨折患者的血浆FFA水平仅略高于健康空腹受试者的值。这些发现表明，来自外周脂肪组织的动员FFA在FES的发病机制中并不重要，但不排除主要来源于肺内甘油三酯栓子水解的FFA的作用。
