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一名非艾滋病毒感染者且注射毒品者患隐球菌性脑膜炎的另一病例:一个需要进一步调查的可能危险因素。

Another case of cryptococcal meningitis in a person without HIV who injects drugs: A possible risk factor in need of further investigation.

作者信息

McCrary L Madeline, Paulus Ryan, Melvin J Kyle, Perfect John, White Becky L

机构信息

UNC Infectious Diseases, 130 Mason Farm Rd, CB# 7030, Chapel Hill, NC, 27599, USA.

UNC Family Medicine, 590 Manning Dr, CB# 7595, Chapel Hill, NC, 27599, USA.

出版信息

Med Mycol Case Rep. 2022 May 11;36:35-36. doi: 10.1016/j.mmcr.2022.05.002. eCollection 2022 Jun.

DOI:10.1016/j.mmcr.2022.05.002
PMID:35602762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9118350/
Abstract

Cryptococcal meningitis is a fungal central nervous infection typically occurring in patients with severe immunocompromise. We present a case of cryptococcal meningitis occurring in a patient with active injection drug use (IDU) but no immunocompromising condition. This is the seventh case in the recent literature of cryptococcal central nervous involvement in an otherwise healthy young person with IDU, suggesting a possible association in need of further exploration.

摘要

隐球菌性脑膜炎是一种真菌性中枢神经系统感染,通常发生在严重免疫功能低下的患者中。我们报告一例隐球菌性脑膜炎病例,该患者有注射吸毒(IDU)行为但无免疫功能低下情况。这是近期文献中第七例原本健康的年轻注射吸毒者发生隐球菌中枢神经系统感染的病例,提示可能存在需要进一步探索的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dbf/9118350/23f085238e48/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dbf/9118350/23f085238e48/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dbf/9118350/23f085238e48/fx1.jpg

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本文引用的文献

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Cryptococcus meningitis mimicking cerebral septic emboli, a case report series demonstrating injection drug use as a risk factor for development of disseminated disease.隐球菌性脑膜炎模拟脑脓毒性栓子,一组病例报告系列表明,注射吸毒是导致播散性疾病发生的一个危险因素。
BMC Infect Dis. 2020 May 27;20(1):381. doi: 10.1186/s12879-020-05108-1.
2
Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies.所有阿片类药物都具有相同的免疫调节特性吗?来自动物和人类研究的综述。
Front Immunol. 2019 Dec 12;10:2914. doi: 10.3389/fimmu.2019.02914. eCollection 2019.
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Cryptococcal meningitis mimicking cerebral infarction: a case report.
年轻免疫功能正常患者的隐球菌性脑膜炎:单中心回顾性病例系列及文献综述
Open Forum Infect Dis. 2023 Aug 11;10(8):ofad420. doi: 10.1093/ofid/ofad420. eCollection 2023 Aug.
隐球菌性脑膜炎误诊为脑梗死:1 例报告。
Clin Interv Aging. 2018 Oct 12;13:1999-2002. doi: 10.2147/CIA.S181774. eCollection 2018.
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Opioids and the immune system - friend or foe.阿片类药物与免疫系统:是敌是友?
Br J Pharmacol. 2018 Jul;175(14):2717-2725. doi: 10.1111/bph.13750. Epub 2017 Mar 23.
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Cases of disseminated cryptococcosis in intravenous drug abusers without HIV infection: A new risk factor?无HIV感染的静脉注射吸毒者发生播散性隐球菌病:一种新的危险因素?
Med Mycol Case Rep. 2016 Dec 2;14:17-19. doi: 10.1016/j.mmcr.2016.12.003. eCollection 2016 Dec.
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Methamphetamine enhances Cryptococcus neoformans pulmonary infection and dissemination to the brain.甲基苯丙胺增强新型隐球菌肺部感染和向大脑的播散。
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