Yossef Kristena, Naidoo Shiva F, Lai William, Levaka Veera Raghava Reddy
Internal Medicine, Geisinger Health System, Danville, USA.
Internal Medicine, Geisinger Health System, Wilkes-Barre, USA.
Cureus. 2022 Apr 19;14(4):e24291. doi: 10.7759/cureus.24291. eCollection 2022 Apr.
Hypophysitis is the inflammation of the pituitary gland with varying effects on hormone function that may be present secondary to the use of certain medications, infections, systemic inflammatory disorders, and other etiologies. Immunotherapy-related hypophysitis is a rare phenomenon. However, it represents an indication of treatment interruption. We report a 60-year-old female with renal clear cell carcinoma on Nivolumab and Ipilimumab (NIVO/IPI) intravenously (IV). After the second cycle of therapy, the patient reported a fall, with associated lightheadedness, dizziness, nausea, vomiting, and hot flashes. The patient's symptoms and history were concerning for hypophysitis, so early treatment and cessation of the checkpoint inhibitors led to the patient's clinical improvement.
垂体炎是垂体的炎症，对激素功能有不同影响，可能继发于某些药物使用、感染、全身性炎症性疾病及其他病因。免疫治疗相关的垂体炎是一种罕见现象。然而，它提示治疗需要中断。我们报告一名60岁女性，因肾透明细胞癌接受静脉注射纳武单抗和伊匹单抗（NIVO/IPI）治疗。在第二个治疗周期后，患者报告跌倒，并伴有头晕、眩晕、恶心、呕吐和潮热。患者的症状和病史提示垂体炎，因此早期治疗及停用检查点抑制剂使患者临床症状改善。
