Department of Food and Nutrition, Gangneung-Wonju National University, Gangneung-si, Korea.
Division of Gastroenterology, Department of Internal Medicine, Hanyang University Guri Hospital, Guri-si, Korea.
Nutr Cancer. 2022;74(10):3501-3508. doi: 10.1080/01635581.2022.2077383. Epub 2022 May 23.
Sodium and zinc display opposite effects on immune cells, such as regulatory T cells (Tregs) and T helper 17 cells (Th17), resulting in an altered immune response. Immune cells have a pivotal role in regulating tumor progression, which may affect gastric cancer (GC) mortality. Thus, this cohort study investigated the associations between the combination of sodium and zinc intake and GC mortality and whether these associations differ by histological type by following up deaths of GC cases in Korea. A total of 490 patients with GC were enrolled between 2002 and 2006. Survival or death was prospectively followed up until December 31, 2016. Finally, 300 patients with the two main histological types of GC were included; 99 GC deaths occurred during a median follow-up period of 7.1 years. Patients with high sodium and low zinc intake had a significantly higher GC mortality than those with low sodium and high zinc intake (hazard ratio [HR], 2.07; 95% confidence interval [CI], 1.09-3.93). However, no significant association was found between the histological types of GC. In conclusion, we found that high sodium and low zinc intake may worsen the survival rate of patients with GC.
钠和锌对免疫细胞（如调节性 T 细胞[Tregs]和辅助性 T 细胞 17[Th17]）有相反的影响，导致免疫反应改变。免疫细胞在调节肿瘤进展中起着关键作用，这可能会影响胃癌（GC）的死亡率。因此，这项队列研究通过随访韩国的 GC 病例死亡情况，调查了钠和锌摄入的组合与 GC 死亡率之间的关系，以及这些关系是否因组织学类型而有所不同。共纳入 2002 年至 2006 年间的 490 例 GC 患者。前瞻性随访生存或死亡情况，直至 2016 年 12 月 31 日。最后，纳入了 300 例具有两种主要 GC 组织学类型的患者；中位随访 7.1 年后发生 99 例 GC 死亡。高钠低锌摄入的患者 GC 死亡率明显高于低钠高锌摄入的患者（风险比[HR]，2.07；95%置信区间[CI]，1.09-3.93）。然而，GC 的组织学类型之间没有发现显著的关联。总之，我们发现高钠和低锌摄入可能会降低 GC 患者的生存率。
