Kubota H, Suda M, Yamada H, Kobayashi Y, Yamamoto H
Jpn J Antibiot. 1986 Dec;39(12):3311-28.
Peri- and post-natal effect of HAPA-B, a new aminoglycoside antibiotic, was studied in Jcl: Wistar rats. The antibiotic was given intramuscularly to dams at doses of 25, 100 and 200 mg/kg from day 17 of gestation to 21 days after delivery and throughout lactation. Influences of the drug on dams and their offspring were studied. A decrease in food intake and an increase in water intake were observed in the 200 mg/kg treated group. At autopsy of dams after weaning, pale discoloration and hypertrophy of the kidney were observed in 100 and 200 mg/kg groups. All other observations including delivery and nursing performance of dams, postnatal development of offspring, behavior and reproduction performance of the offspring were normal. The no effect dose level of HAPA-B found in this study was 25 mg/kg on rat dams and 100 mg/kg on the offspring.
在Jcl:Wistar大鼠中研究了一种新型氨基糖苷类抗生素HAPA - B的围产期和产后效应。从妊娠第17天到产后21天及整个哺乳期，以25、100和200mg/kg的剂量给母鼠肌肉注射该抗生素。研究了该药物对母鼠及其后代的影响。在200mg/kg治疗组中观察到食物摄入量减少和饮水量增加。断奶后对母鼠进行尸检时，在100和200mg/kg组中观察到肾脏苍白变色和肥大。所有其他观察结果，包括母鼠的分娩和哺乳表现、后代的产后发育、行为以及后代的繁殖性能均正常。本研究中发现的HAPA - B对大鼠母鼠的无效应剂量水平为25mg/kg，对后代为100mg/kg。
