Rai Mahendra, Zimowska Beata, Gade Aniket, Ingle Pramod
Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati, 444 602, Maharashtra, India.
Department of Microbiology, Nicolaus Copernicus University, 87-100, Toruń, Poland.
AMB Express. 2022 May 23;12(1):60. doi: 10.1186/s13568-022-01404-y.
The increasing multidrug-resistance in pathogenic microbes and the emergence of new microbial pathogens like coronaviruses have necessitated the discovery of new antimicrobials to treat these pathogens. The use of antibiotics began after the discovery of penicillin by Alexander Fleming from Penicillium chrysogenum. This has attracted the scientific community to delve deep into the antimicrobial capabilities of various fungi in general and Phoma spp. in particular. Phoma spp. such as Phoma arachidicola, P. sorghina, P. exigua var. exigua, P. herbarum, P. multirostrata, P. betae, P. fimeti, P. tropica, among others are known to produce different bioactive metabolites including polyketides, macrosporin, terpenes and terpenoids, thiodiketopiperazines, cytochalasin derivatives, phenolic compounds, and alkaloids. These bioactive metabolites have already demonstrated their antimicrobial potential (antibacterial, antifungal, and antiviral) against various pathogens. In the present review, we have discussed the antimicrobial potential of secondary metabolites produced by different Phoma species. We have also deliberated the biogenic synthesis of eco-friendly antimicrobial silver nanoparticles from Phoma and their role as potential antimicrobial agents.
致病微生物中日益增加的多重耐药性以及新型微生物病原体如冠状病毒的出现，使得发现新的抗菌药物来治疗这些病原体成为必要。抗生素的使用始于亚历山大·弗莱明从产黄青霉中发现青霉素之后。这吸引了科学界深入研究各种真菌，尤其是茎点霉属真菌的抗菌能力。已知诸如花生茎点霉、高粱茎点霉、极小茎点霉、草本茎点霉、多喙茎点霉、甜菜茎点霉、粪生茎点霉、热带茎点霉等多种茎点霉能产生不同的生物活性代谢产物，包括聚酮类化合物、大孢菌素、萜类和萜类化合物、硫代二酮哌嗪、细胞松弛素衍生物、酚类化合物和生物碱。这些生物活性代谢产物已显示出对各种病原体的抗菌潜力（抗菌、抗真菌和抗病毒）。在本综述中，我们讨论了不同茎点霉属物种产生的次生代谢产物的抗菌潜力。我们还探讨了利用茎点霉进行生态友好型抗菌银纳米颗粒的生物合成及其作为潜在抗菌剂的作用。
