Miao Chun-Bao, Qiang Xiao-Qi, Xu Xiaoli, Song Xiao-Qing, Zhou Su-Qing, Lyu Xinyu, Yang Hai-Tao
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, School of Petrochemical Engineering, School of Environmental and Safety Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China.
Org Lett. 2022 Jun 3;24(21):3828-3833. doi: 10.1021/acs.orglett.2c01386. Epub 2022 May 23.
A copper-catalyzed annulation of -unsaturated -acyl ketoximes with isoquinolinium -ylides has been developed for the concise synthesis of stable N-H imines with a benzo[7,8]indolizine core. When β-(2-bromoaryl)--unsaturated -acyl ketoximes are used as the starting materials, a cascade cyclization occurs to afford the benzo[7,8]indolizino[1,2-]quinolines.
已开发出一种铜催化的α,β-不饱和α-酰基酮肟与异喹啉鎓叶立德的环化反应，用于简洁合成具有苯并[7,8]吲哚嗪核心的稳定N-H亚胺。当β-(2-溴芳基)-α,β-不饱和α-酰基酮肟用作起始原料时，会发生串联环化反应，生成苯并[7,8]吲哚并[1,2-a]喹啉。
