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Synthesis of 2,4,6-Trisubstituted Pyrimidines through Copper-Catalyzed [4 + 2] Annulation of α,β-Unsaturated Ketoximes with Activated Nitriles.

作者信息

Wang Xuemei, Yan Huan, Jia Chenglong, Fang Zheng, Duan Jindian, Guo Kai

机构信息

College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.

出版信息

J Org Chem. 2023 Sep 1;88(17):12236-12243. doi: 10.1021/acs.joc.3c00687. Epub 2023 Aug 23.

DOI:10.1021/acs.joc.3c00687
PMID:37610229
Abstract

The copper-catalyzed [4 + 2] annulation of α,β-unsaturated ketoximes with activated nitriles for the rapid construction of 2,4,6-trisubstituted pyrimidines in moderate to good yields has been developed. The reaction features synthetic simplicity, good functional group tolerance, and gram-scale applicability. A plausible mechanism is proposed based on mechanistic investigations.

摘要

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