Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China.
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Advanced catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University , Changzhou 213164, P. R. China .
J Org Chem. 2017 Sep 15;82(18):9291-9304. doi: 10.1021/acs.joc.7b01042. Epub 2017 Aug 11.
The Cu-catalyzed three-component reaction between quinolines, diazo compounds, and alkenes has been established for direct construction of indolizine derivatives via quinolinium ylides. This methodology is distinguished by the use of a commercially inexpensive catalyst and readily available starting materials, wide substrate scope, and operational simplicity.
喹啉、重氮化合物和烯烃的铜催化三组分反应已经建立，通过喹啉翁叶立德可以直接构建吲哚嗪衍生物。该方法的特点是使用商业上廉价的催化剂和易得的起始原料、广泛的底物范围和操作简单。
