College of Pharmacy, Guilin Medical University, Guilin, 541004, People's Republic of China.
College of Pharmacy, Guilin Medical University, Guilin, 541004, People's Republic of China.
Phytochemistry. 2022 Aug;200:113246. doi: 10.1016/j.phytochem.2022.113246. Epub 2022 May 20.
Eighteen undescribed xanthones, including six pairs of xanthone enantiomers, three xanthones, and three xanthone glycosides, together with one pair of known xanthone enantiomers and 12 known xanthones, were isolated from the stems of Calophyllum membranaceum Gardn. et Champ. Their structures were elucidated by spectroscopic analysis, and the absolute configuration of the enantiomers was determined by using experimental and calculated electronic circular dichroism data. All compounds were screened for their anti-inflammatory effects on LPS-induced BV-2 microglial cells. Among them, six compounds showed remarkable activities with IC values of 7.8-36.0 μM.
从 Calophyllum membranaceum Gardn. et Champ. 的茎中分离得到 18 种未描述的紫檀烷，包括 6 对紫檀烷对映异构体、3 种紫檀烷和 3 种紫檀烷糖苷，以及 1 对已知的紫檀烷对映异构体和 12 种已知的紫檀烷。通过光谱分析阐明了它们的结构，并通过实验和计算的电子圆二色性数据确定了对映异构体的绝对构型。所有化合物均进行了 LPS 诱导的 BV-2 小胶质细胞的抗炎活性筛选。其中，有 6 种化合物表现出显著的活性，IC 值为 7.8-36.0 μM。
