Cognitive and Systems Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.
Research Priority Area Brain and Cognition, University of Amsterdam, Amsterdam, The Netherlands.
Nat Commun. 2022 May 23;13(1):2864. doi: 10.1038/s41467-022-30600-4.
Primary sensory areas constitute crucial nodes during perceptual decision making. However, it remains unclear to what extent they mainly constitute a feedforward processing step, or rather are continuously involved in a recurrent network together with higher-order areas. We found that the temporal window in which primary visual cortex is required for the detection of identical visual stimuli was extended when task demands were increased via an additional sensory modality that had to be monitored. Late-onset optogenetic inactivation preserved bottom-up, early-onset responses which faithfully encoded stimulus features, and was effective in impairing detection only if it preceded a late, report-related phase of the cortical response. Increasing task demands were marked by longer reaction times and the effect of late optogenetic inactivation scaled with reaction time. Thus, independently of visual stimulus complexity, multisensory task demands determine the temporal requirement for ongoing sensory-related activity in V1, which overlaps with report-related activity.
初级感觉区域在感知决策过程中构成关键节点。然而，它们主要构成前馈处理步骤的程度，或者与高阶区域一起持续参与递归网络，这一点尚不清楚。我们发现，当通过必须监测的额外感觉模态增加任务需求时，初级视觉皮层检测相同视觉刺激所需的时间窗口会延长。晚期发作的光遗传学失活保留了自下而上的、早期发作的反应，这些反应忠实地编码了刺激特征，并且只有在它先于皮质反应的晚期、与报告相关的阶段时才会有效地损害检测。增加任务需求的标志是更长的反应时间，并且晚期光遗传学失活的效果与反应时间成正比。因此，独立于视觉刺激的复杂性，多感官任务需求决定了 V1 中正在进行的与感觉相关的活动的时间要求，该活动与报告相关的活动重叠。
