Perez-Baena Irma, Barroso-Bujans Fabienne, Gasser Urs, Arbe Arantxa, Moreno Angel J, Colmenero Juan, Pomposo José A
Centro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center, Paseo Manuel de Lardizabal 5, 20018 San Sebastián, Spain.
Laboratory for Neutron Scattering, Paul Scherrer Institut, CH-5232 Villigen, Switzerland.
ACS Macro Lett. 2013 Sep 17;2(9):775-779. doi: 10.1021/mz4003744. Epub 2013 Aug 15.
The development of simple, efficient, and robust strategies affording the facile construction of biomimetic organocatalytic nano-objects is currently a subject of great interest. Herein, a new pathway to artificial organocatalysts based on partially collapsed individual soft nano-objects displaying useful and diverse biomimetic catalytic functions is reported. Single-chain polymer nanoparticles endowed with enzyme-mimetic activity synthesized following this new route display (i) a relatively extended morphology under good solvent conditions, as revealed by small angle neutron scattering and coarse-grained molecular dynamics simulation results, (ii) multiple, compartmentalized, and accessible catalytic sites in which borane catalytic units are retained via B···O interactions, and (iii) unprecedented reductase and polymerase enzyme-mimetic properties.
开发简单、高效且稳健的策略以实现仿生有机催化纳米物体的简便构建，是当前备受关注的课题。在此，我们报道了一条基于部分塌陷的单个软纳米物体构建人工有机催化剂的新途径，这些纳米物体展现出有用且多样的仿生催化功能。按照这条新路线合成的具有酶模拟活性的单链聚合物纳米颗粒表现出：（i）在良好溶剂条件下具有相对伸展的形态，小角中子散射和粗粒化分子动力学模拟结果表明了这一点；（ii）多个分隔且可及的催化位点，其中硼烷催化单元通过B···O相互作用得以保留；（iii）前所未有的还原酶和聚合酶模拟特性。
