Thümmler Justus Friedrich, Golmohamadi Farzin Ghane, Schöffmann Daniel, Laufer Jan, Lucas Henrike, Kollan Julia, Mäder Karsten, Binder Wolfgang Hubertus
Institute of Chemistry, Faculty of Natural Science II, Martin Luther University Halle-Wittenberg, von-Danckelmann-Platz 4, Halle, Saale, D-06120, Germany.
Institute of Physics, Faculty of Natural Science II, Martin Luther University Halle-Wittenberg, von-Danckelmann-Platz 3, Halle, Saale, D-06120, Germany.
Commun Chem. 2025 Apr 25;8(1):124. doi: 10.1038/s42004-025-01518-x.
Irradiating a chromophore allows cancer diagnostics by photoacoustic (PA) imaging, but also causes transformation of light into thermal energy and so enables therapy by photothermal effects. Useful chromophores for photothermal therapy (PTT), such as nanoconfined oligomers and polymers, should not only display an excellent light-to-heat efficiency, but in addition must display biocompatibility and good water-solubility. We in this study have designed water-dispersible, nanocaged polypyrroles (PPy), embedded into single-chain nanoparticles (SCNP, sized 6.8 - 8.9 nm) displaying thermoresponsivity, so reaching largely increased PTT-effects. Such encaged PPy-SCNPs allow an efficient photothermal heat conversion reaching temperatures up to 85°C. In a parallelized 96-well-plate-design the PPy-SCNPs can effect an almost complete death of illuminated (cancer) cells at already low concentrations (0.001 mg/mL) with low radiant fluxes. The thermoresponsivity of the SCNPs, surrounding the PPy-chains, then responds to the photothermal heat, so creating a unique self-amplifying effect for photothermal therapy and photoacoustic imaging.
对发色团进行辐照不仅可以通过光声（PA）成像进行癌症诊断，还能将光转化为热能，从而实现光热效应治疗。用于光热疗法（PTT）的有用发色团，如纳米受限低聚物和聚合物，不仅应具有出色的光热转换效率，还必须具有生物相容性和良好的水溶性。在本研究中，我们设计了嵌入具有热响应性的单链纳米颗粒（SCNP，尺寸为6.8 - 8.9nm）中的水分散性纳米笼状聚吡咯（PPy），从而大大增强了光热治疗效果。这种笼状PPy-SCNP能实现高效的光热转换，温度可达85°C。在96孔板平行设计中，PPy-SCNP在低辐射通量下，即使在低浓度（0.001mg/mL）时也能使被照射的（癌症）细胞几乎完全死亡。围绕PPy链的SCNP的热响应性会对光热产生响应，从而为光热治疗和光声成像创造独特的自增强效应。
