Sun Shuangyi, Chamsaz Elaheh A, Joy Abraham
Department of Polymer Science, The University of Akron, Akron, Ohio 44325, United States.
ACS Macro Lett. 2012 Oct 16;1(10):1184-1188. doi: 10.1021/mz3002947. Epub 2012 Sep 21.
We report the design and development of a new class of alkoxyphenacyl based photodegradable polycarbonates. These polymers incorporate the photoactive moiety in the backbone and, when irradiated at 300 nm, undergo controlled chain scission. Micropatterned thin films of these polymers were fabricated by photolithographic techniques. The use of these photodegradable polymers for controlled release applications was demonstrated by the release of Nile Red from polymeric nanoparticles. In addition, these polymers are mechanically robust, thermally stable, and hydrolytically degradable.
我们报告了一类新型的基于烷氧基苯甲酰基的光降解聚碳酸酯的设计与开发。这些聚合物在主链中引入了光活性部分，在300nm波长照射下会发生可控的链断裂。通过光刻技术制备了这些聚合物的微图案薄膜。通过尼罗红从聚合物纳米颗粒中的释放，证明了这些光降解聚合物在控释应用中的用途。此外，这些聚合物具有机械强度高、热稳定性好和可水解降解的特点。
