A core group of structurally similar HLA-DPB1 alleles drives permissiveness after hematopoietic cell transplantation.
作者信息
Arrieta-Bolaños Esteban, Crivello Pietro, He Meilun, Wang Tao, Gadalla Shahinaz M, Paczesny Sophie, Marsh Steven G E, Lee Stephanie J, Spellman Stephen R, Bolon Yung-Tsi, Fleischhauer Katharina
机构信息
Institute for Experimental Cellular Therapy, University Hospital Essen, Essen, Germany.
German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Essen, Germany.
出版信息
Blood. 2022 Aug 11;140(6):659-663. doi: 10.1182/blood.2022015708.
Abstract
摘要
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Analysis of biological models to predict clinical outcomes based on HLA-DPB1 disparities in unrelated transplantation.基于非亲缘移植中HLA - DPB1差异预测临床结局的生物学模型分析
Blood Adv. 2021 Sep 14;5(17):3377-3386. doi: 10.1182/bloodadvances.2020003998.
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Permissive HLA-DPB1 mismatches in HCT depend on immunopeptidome divergence and editing by HLA-DM.在 HCT 中，允许的 HLA-DPB1 错配取决于免疫肽组的差异和 HLA-DM 的编辑。
Blood. 2021 Feb 18;137(7):923-928. doi: 10.1182/blood.2020008464.
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J Clin Oncol. 2020 Aug 20;38(24):2712-2718. doi: 10.1200/JCO.20.00265. Epub 2020 Jun 1.
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Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies.免疫肽组学分析 HLA-DPB1 等位基因变异揭示新的功能层次结构。
J Immunol. 2020 Jun 15;204(12):3273-3282. doi: 10.4049/jimmunol.2000192. Epub 2020 Apr 29.
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Common, intermediate and well-documented HLA alleles in world populations: CIWD version 3.0.0.世界人群中常见、中等频率且记录完善的HLA等位基因：CIWD版本3.0.0
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Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes.通过免疫肽组学中深度基序反卷积技术对 HLA Ⅱ类表位进行稳健预测。
Nat Biotechnol. 2019 Nov;37(11):1283-1286. doi: 10.1038/s41587-019-0289-6. Epub 2019 Oct 14.
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Protective effect of HLA-DPB1 mismatch remains valid in reduced-intensity conditioning unrelated donor hematopoietic cell transplantation.HLA-DPB1错配在减低强度预处理非血缘供者造血细胞移植中的保护作用仍然有效。
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