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肝脏不常见的良性肿瘤和假肿瘤。

Uncommon Benign Neoplasms and Pseudotumors of the Liver.

机构信息

From the Department of Pathology, University of Michigan, Ann Arbor (Assarzadegan); and the Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida (Montgomery).

出版信息

Arch Pathol Lab Med. 2023 Apr 1;147(4):390-402. doi: 10.5858/arpa.2021-0539-RA.

DOI:10.5858/arpa.2021-0539-RA
PMID:35609332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10443935/
Abstract

CONTEXT.—: The most common benign hepatic mass-forming lesions often display fairly specific imaging characteristics, whereas less familiar, rarer benign neoplasms and pseudotumors may pose a diagnostic challenge in clinical, radiology, and pathology practice because of either their rarity or their unusual features.

OBJECTIVE.—: To review a selection of pseudotumors and unusual benign hepatic neoplasms encountered in consultation practices with a focus on nonepithelial tumors.

DATA SOURCES.—: Sources include English-language literature and personal experiences.

CONCLUSIONS.—: Several benign conditions (namely, segmental atrophy, infections, immunoglobulin G4 [IgG4]-related sclerosing disease, angiomyolipoma, mesenchymal hamartoma, and various vascular lesions) can lead to formation of hepatic masses. Because of their rarity and underrecognition, such lesions are often diagnostically challenging. Awareness of hepatic pseudotumors and various rare hepatic neoplasms and their potential mimics can forestall misdiagnosis and inappropriate management.

摘要

背景

最常见的良性肝脏肿块形成病变通常具有相当特定的影像学特征,而不太常见的、罕见的良性肿瘤和假肿瘤由于其罕见性或不常见的特征,可能在临床、放射学和病理学实践中构成诊断挑战。

目的

回顾在会诊实践中遇到的一系列假肿瘤和罕见的良性肝脏肿瘤,重点是非上皮性肿瘤。

资料来源

资料来源包括英语文献和个人经验。

结论

几种良性疾病(即节段性萎缩、感染、免疫球蛋白 G4[IgG4]相关硬化性疾病、血管平滑肌脂肪瘤、间叶性错构瘤和各种血管病变)可导致肝脏肿块形成。由于其罕见性和认识不足,此类病变的诊断通常具有挑战性。了解肝脏假肿瘤和各种罕见的肝脏肿瘤及其潜在的类似物,可以避免误诊和不适当的治疗。

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本文引用的文献

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Hepat Oncol. 2020 Apr 7;7(2):HEP19. doi: 10.2217/hep-2020-0002.
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Regenerative hepatic pseudotumor: a new pseudotumor of the liver.再生性肝假瘤:一种新的肝脏假瘤。
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Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.肝间叶性错构瘤和 DICER1 综合征。
N Engl J Med. 2019 May 9;380(19):1834-1842. doi: 10.1056/NEJMoa1812169.
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Morphologic Overlap Between Inflammatory Myofibroblastic Tumor and IgG4-related Disease: Lessons From Next-generation Sequencing.炎性肌纤维母细胞瘤与 IgG4 相关疾病的形态学重叠:下一代测序的启示。
Am J Surg Pathol. 2019 Mar;43(3):314-324. doi: 10.1097/PAS.0000000000001167.
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Hepatic angiomyolipoma: mutation analysis and immunohistochemical pitfalls in diagnosis.肝血管平滑肌脂肪瘤:基因突变分析及诊断中的免疫组化陷阱。
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